{"id":"W2047865806","doi":"10.1006/bbrc.2001.5147","title":"cAMP Protection of Pancreatic Cancer Cells against Apoptosis Induced by ERK Inhibition","year":2001,"lang":"en","type":"article","venue":"Biochemical and Biophysical Research Communications","topic":"Phosphodiesterase function and regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":43,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université de Sherbrooke","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Forskolin; IBMX; Apoptosis; MAPK/ERK pathway; Downregulation and upregulation; Pancreatic cancer; Cell cycle; Cancer research; Chemistry; Cell growth; Cell biology; Cell culture; Biology; Internal medicine; Kinase; Cancer; Medicine; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000120325,0.0003342799,0.0004563213,0.0002911474,0.0002879855,0.0002509883,0.0002977807,0.0003137959,0.002861569],"category_scores_gemma":[0.0001880662,0.0001848267,0.0003417383,0.0002412606,0.0002597044,0.0002003454,0.0002302543,0.001373948,0.0004710399],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003422484,"about_ca_system_score_gemma":0.0005274902,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001652207,"about_ca_topic_score_gemma":0.001711131,"domain_scores_codex":[0.9998814,0.00001647808,0.000008672081,0.00001217309,0.00001860428,0.0000626722],"domain_scores_gemma":[0.9999083,0.00002783697,0.000007531118,0.00002210057,0.00001335006,0.00002085907],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.003112021,0.000356795,0.0003832944,0.0003069399,0.00003406289,0.0003372003,0.0001020579,0.0003182779,0.9848365,0.0005930132,0.0007491497,0.008870707],"study_design_scores_gemma":[0.000207298,0.001291213,0.004027219,0.0000303669,0.00003838824,0.0004291935,0.00009534583,0.0008090804,0.9882813,0.000212069,0.004569127,0.000009327968],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9871922,0.005221986,0.0007401526,0.0005734201,0.0001456799,0.00004365691,0.0007416593,0.0001229143,0.005218243],"genre_scores_gemma":[0.9935595,0.002215467,0.000552459,0.00008947779,0.00002937465,0.00004061903,0.0008501752,0.00000858567,0.002654443],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002861569,"threshold_uncertainty_score":0.009572864,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0560913117128305,"score_gpt":0.3361786872436547,"score_spread":0.2800873755308242,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}