{"id":"W2047929869","doi":"10.1016/j.yexcr.2010.05.012","title":"Dimerization drives PDGF receptor endocytosis through a C-terminal hydrophobic motif shared by EGF receptor","year":2010,"lang":"en","type":"article","venue":"Experimental Cell Research","topic":"Cellular transport and secretion","field":"Biochemistry, Genetics and Molecular Biology","cited_by":24,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Alberta","funders":"Canadian Institutes of Health Research; Alberta Heritage Foundation for Medical Research; Ariad Pharmaceuticals","keywords":"Internalization; Platelet-derived growth factor receptor; Cell biology; Biology; Endocytosis; Autophosphorylation; Tyrosine kinase; Receptor tyrosine kinase; Signal transduction; Kinase; Receptor; Biochemistry; Growth factor; Protein kinase A","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.000263305,0.0002259068,0.0001654475,0.00006924348,0.0003670484,0.0001187998,0.0003613141,0.0002670367,0.002607296],"category_scores_gemma":[0.00001965757,0.0002296718,0.000127054,0.0001999101,0.000356027,0.00002385931,0.0001391115,0.0004204374,0.0002456377],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000412284,"about_ca_system_score_gemma":0.00009729256,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001370781,"about_ca_topic_score_gemma":0.00001426074,"domain_scores_codex":[0.997901,0.0001413975,0.0002585768,0.0006457039,0.0005188233,0.0005345536],"domain_scores_gemma":[0.9991913,0.00001859878,0.00005844259,0.0004465083,0.0001049243,0.0001801941],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002162002,0.0003695622,0.0007046136,0.00001747862,0.00001647126,0.000004066086,0.0006650941,6.948165e-7,0.9938435,0.00001974427,0.003993784,0.0001487746],"study_design_scores_gemma":[0.0005388536,0.0004621688,0.00006815238,0.000007734646,0.000003299701,0.000003698149,0.0004122778,0.0000308878,0.7843885,0.000005924705,0.2138795,0.000198985],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.993457,0.001430621,0.0006041474,0.00008232113,0.0003872021,0.0004324315,0.00007176497,0.00002615574,0.003508418],"genre_scores_gemma":[0.9814337,0.0003196944,0.0009994494,0.00004562348,0.0003747535,0.0001301968,0.01200383,0.00005730877,0.004635414],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2098857,"threshold_uncertainty_score":0.9983044,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0213949353683755,"score_gpt":0.3166281599585913,"score_spread":0.2952332245902158,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}