{"id":"W2047961242","doi":"10.1021/bi991682+","title":"Human Immunodeficiency Virus Type 1 Reverse Transcriptase Dimer Destabilization by 1-{Spiro[4‘ ‘-amino-2‘ ‘,2‘ ‘-dioxo-1‘ ‘,2‘ ‘-oxathiole-5‘ ‘,3‘- [2‘,5‘-bis-<i>O</i>-(<i>tert</i>-butyldimethylsilyl)-β-<scp>d</scp>-ribofuranosyl]]}-3-ethylthymine","year":2000,"lang":"en","type":"article","venue":"Biochemistry","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":66,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; University of Waterloo","funders":"","keywords":"Dimer; Protein subunit; Chemistry; Reverse transcriptase; Enzyme; Stereochemistry; Crystallography; Biochemistry; Gene; RNA","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":["insufficient_payload"],"category_scores_codex":[0.0004028048,0.0007468449,0.0006535926,0.0001280013,0.0007228716,0.00008295604,0.0007570715,0.000841587,0.004911946],"category_scores_gemma":[0.0002639567,0.0007066721,0.000323707,0.0006066583,0.0006444907,0.0002268463,0.0000920573,0.000794976,0.003343937],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002238913,"about_ca_system_score_gemma":0.0002657129,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003980655,"about_ca_topic_score_gemma":0.00001255883,"domain_scores_codex":[0.9960809,0.0003112559,0.0008122261,0.001176803,0.0002493356,0.001369452],"domain_scores_gemma":[0.9979794,0.0002092216,0.000195165,0.001174284,0.0002123799,0.0002295188],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001075001,0.001142748,0.001271707,0.00009562601,0.0002154784,0.00004343537,0.0003585175,0.000004910731,0.9363658,0.0000136705,0.05705058,0.00333007],"study_design_scores_gemma":[0.002514462,0.0004357006,0.0006531952,0.0000618261,0.000139459,0.00008886466,0.0002233396,0.000002868757,0.7877197,0.00002003904,0.2078139,0.0003266452],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9620416,0.02617045,0.00004061753,0.0001303013,0.0003467984,0.0005966782,0.001226305,0.0002979148,0.009149387],"genre_scores_gemma":[0.92806,0.001176908,0.0001179962,0.0003182415,0.00007907084,0.0001207327,0.005611492,0.00009679075,0.06441878],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1507633,"threshold_uncertainty_score":0.9995384,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01120363449164152,"score_gpt":0.248238214251161,"score_spread":0.2370345797595194,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}