{"id":"W2047961242","doi":"10.1021/bi991682+","title":"Human Immunodeficiency Virus Type 1 Reverse Transcriptase Dimer Destabilization by 1-{Spiro[4‘ ‘-amino-2‘ ‘,2‘ ‘-dioxo-1‘ ‘,2‘ ‘-oxathiole-5‘ ‘,3‘- [2‘,5‘-bis-<i>O</i>-(<i>tert</i>-butyldimethylsilyl)-β-<scp>d</scp>-ribofuranosyl]]}-3-ethylthymine","year":2000,"lang":"en","type":"article","venue":"Biochemistry","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":66,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; University of Waterloo","funders":"","keywords":"Dimer; Protein subunit; Chemistry; Reverse transcriptase; Enzyme; Stereochemistry; Crystallography; Biochemistry; Gene; RNA","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009954029,0.0001467805,0.0001310599,0.00003189196,0.00009631094,0.0001361013,0.000175849,0.0001352168,0.0007968458],"category_scores_gemma":[0.0001150232,0.00009392558,0.0001189364,0.00003765045,0.0001048067,0.0001192129,0.0001299439,0.0002924555,0.0001374668],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001245754,"about_ca_system_score_gemma":0.0001155685,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003754915,"about_ca_topic_score_gemma":0.0006230091,"domain_scores_codex":[0.9999344,0.00001571082,0.000003244947,0.00001580967,0.00001499213,0.00001582844],"domain_scores_gemma":[0.9999684,0.000007761611,0.00001029051,0.000003012004,0.000003049127,0.000007451084],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001481074,0.00003438765,0.0001508543,0.00002432636,0.000008757923,0.00002835884,0.00003286065,0.0002679458,0.9977804,0.00007844224,0.000032101,0.00141352],"study_design_scores_gemma":[0.00001793762,0.0002115986,0.001173868,0.000003187729,0.000005968716,0.00006195793,0.00001718822,0.001774811,0.9961409,0.00002453368,0.0005639591,0.000004160172],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9988306,0.0002752961,0.0004232835,0.00002061404,0.000007026534,0.000004768754,0.00001769171,0.00001181643,0.0004089736],"genre_scores_gemma":[0.9988683,0.0001609188,0.0002834901,0.00001676236,0.000001737975,0.000004758943,0.0000414249,0.000007499488,0.0006149812],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007968458,"threshold_uncertainty_score":0.002665758,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01120363449164152,"score_gpt":0.248238214251161,"score_spread":0.2370345797595194,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}