{"id":"W2047995544","doi":"10.1074/jbc.m109.028431","title":"Structural, Functional, and Bioinformatic Studies Demonstrate the Crucial Role of an Extended Peptide Binding Site for the SH3 Domain of Yeast Abp1p","year":2009,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Biochemical and Structural Characterization","field":"Biochemistry, Genetics and Molecular Biology","cited_by":49,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children; University of Toronto","funders":"","keywords":"SH3 domain; Peptide; Binding site; Mutagenesis; Plasma protein binding; Biology; Yeast; Protein–protein interaction; Biochemistry; Binding domain; Function (biology); Saccharomyces cerevisiae; Conserved sequence; Peptide sequence; Computational biology; Biophysics; Cell biology; Proto-oncogene tyrosine-protein kinase Src; Kinase; Mutation; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001150855,0.000371005,0.0002024278,0.0001666332,0.0002003587,0.0001805985,0.0001595114,0.0002170168,0.0008190247],"category_scores_gemma":[0.0001851246,0.00007752051,0.0002637101,0.0002385995,0.0002743532,0.0001476883,0.000186256,0.0004797747,0.0003673736],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000151246,"about_ca_system_score_gemma":0.0001571822,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008460419,"about_ca_topic_score_gemma":0.0008086883,"domain_scores_codex":[0.9999563,0.000005624648,0.000003014349,0.00001229286,0.00001743895,0.000005478991],"domain_scores_gemma":[0.999854,0.0000406828,0.00003459715,0.00001565385,0.00001940199,0.0000356816],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001496273,0.00002967817,0.003175444,0.0001407192,0.00001928819,0.0004131828,0.00005704073,0.0008627049,0.9881072,0.0001608568,0.00008731422,0.006796901],"study_design_scores_gemma":[0.00003874288,0.0004526335,0.1871357,0.00002750344,0.0001507579,0.007536608,0.0002383383,0.01566767,0.7725193,0.0008401349,0.01534607,0.00004659915],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9915892,0.001239161,0.005634991,0.0001107422,0.00001022599,0.00001348869,0.0005977185,0.00008611847,0.0007182342],"genre_scores_gemma":[0.9880071,0.0006088075,0.00839876,0.00005153897,0.00001086911,0.00001726583,0.002286717,0.00001952698,0.0005994568],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008460419,"threshold_uncertainty_score":0.002739906,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02111542829161522,"score_gpt":0.2586039234848241,"score_spread":0.2374884951932089,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}