{"id":"W2048027195","doi":"10.1016/j.canlet.2007.08.016","title":"Induction of the NAD(P)H:quinone oxidoreductase 1 by ketoconazole and itraconazole: A mechanism of cancer chemoprotection","year":2007,"lang":"en","type":"article","venue":"Cancer Letters","topic":"Genomics, phytochemicals, and oxidative stress","field":"Biochemistry, Genetics and Molecular Biology","cited_by":18,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Alberta","funders":"","keywords":"Ketoconazole; NAD+ kinase; Carcinogen; Aryl hydrocarbon receptor; Azole; Enzyme; Chemistry; Itraconazole; Biochemistry; Pharmacology; Biology; Gene; Microbiology; Antifungal; Transcription factor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001127219,0.0001190444,0.0001346523,0.00002443559,0.00004475722,0.000004247863,0.0001188551,0.00009972059,0.00001547292],"category_scores_gemma":[0.00001491407,0.0001021309,0.00005833028,0.00007774367,0.0002048467,0.000005049246,0.00005562383,0.0001005401,1.835363e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003530576,"about_ca_system_score_gemma":0.00004243551,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003711766,"about_ca_topic_score_gemma":0.00008442868,"domain_scores_codex":[0.9992783,0.00001861758,0.0002032761,0.0002342456,0.0000990529,0.0001665222],"domain_scores_gemma":[0.999498,0.000005264531,0.0001958388,0.000190124,0.00006662434,0.0000441845],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008693361,0.00002156972,0.001156704,0.00004610899,0.00005653646,1.391409e-7,0.00008172031,0.00001614756,0.9945056,0.00002716922,0.001778053,0.002223248],"study_design_scores_gemma":[0.0004654724,0.00002961065,0.003875513,0.00002775275,0.00002703467,0.00000253708,0.00008210896,0.000004136215,0.9935288,0.00007417985,0.001771136,0.0001117644],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9955271,0.001962466,0.001030259,0.0007517256,0.0003070915,0.0002939058,0.00009185288,0.00000353457,0.00003205662],"genre_scores_gemma":[0.9984557,0.0003043693,0.0001303683,0.0006510985,0.0003031664,0.0000571779,0.00001899474,0.00001413546,0.00006498815],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002928593,"threshold_uncertainty_score":0.4164776,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005757269269431445,"score_gpt":0.2424074711437134,"score_spread":0.236650201874282,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}