{"id":"W2048035811","doi":"10.1007/s11926-009-0017-1","title":"Tissue stiffness, latent TGF-β1 Activation, and mechanical signal transduction: Implications for the pathogenesis and treatment of fibrosis","year":2009,"lang":"en","type":"article","venue":"Current Rheumatology Reports","topic":"Cellular Mechanics and Interactions","field":"Biochemistry, Genetics and Molecular Biology","cited_by":372,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto","funders":"Competence Centre for Materials Science and Technology; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung","keywords":"Myofibroblast; Fibrosis; Transforming growth factor; Connective tissue; Extracellular matrix; CTGF; Growth factor; Pulmonary fibrosis; Medicine; Cell biology; Pathology; Signal transduction; Biology; Internal medicine; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005119804,0.0003075867,0.0003562689,0.0003714655,0.0002329021,0.001137861,0.000360171,0.0006799349,0.001327665],"category_scores_gemma":[0.0005266194,0.0001405943,0.0001841399,0.0002402745,0.0009198907,0.0009935171,0.0003650869,0.001273838,0.0002436894],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004018632,"about_ca_system_score_gemma":0.0004235626,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000334489,"about_ca_topic_score_gemma":0.0004420166,"domain_scores_codex":[0.9998255,0.00004003719,0.00001543453,0.00001682695,0.0000642395,0.00003798667],"domain_scores_gemma":[0.9997252,0.00008264869,0.00009661532,0.00001411083,0.00002602676,0.00005542017],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.004195087,0.0005997113,0.01047009,0.001937869,0.0000801396,0.001946106,0.0004827813,0.001007375,0.6918232,0.03232384,0.002579994,0.2525538],"study_design_scores_gemma":[0.001391368,0.009964479,0.2319383,0.001340947,0.0006840568,0.02602736,0.003724564,0.01510688,0.4610687,0.1026954,0.1457202,0.0003377577],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.3620708,0.5983648,0.0131114,0.01661094,0.0008734447,0.000038919,0.0001678178,0.0001300304,0.008631873],"genre_scores_gemma":[0.8574011,0.1341542,0.002794644,0.0009116811,0.001072629,0.00003716466,0.00007417695,0.00001262049,0.003541747],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.001327665,"threshold_uncertainty_score":0.0044415,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02145942024831372,"score_gpt":0.2872483175824769,"score_spread":0.2657888973341632,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}