{"id":"W2048043138","doi":"10.1517/17460440802580700","title":"Can<i>in vitro</i>assessment provide relevant end points for cognitive drug programs?","year":2008,"lang":"en","type":"article","venue":"Expert Opinion on Drug Discovery","topic":"Neuroscience and Neuropharmacology Research","field":"Neuroscience","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Boniface Hospital; University of Manitoba","funders":"","keywords":"Long-term potentiation; Neuroscience; Cognition; Nootropic; Drug discovery; Psychology; Synaptic plasticity; Pharmacology; Medicine; Biology; Bioinformatics; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0003701917,0.0003492148,0.0003588207,0.0003061321,0.0005288212,0.0001405501,0.0005682822,0.00005972687,0.00002751635],"category_scores_gemma":[0.0005812456,0.0002981547,0.0001711544,0.000560445,0.0006473939,0.0007757613,0.0002109234,0.0005112285,0.0000470315],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000162912,"about_ca_system_score_gemma":0.000517626,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006122267,"about_ca_topic_score_gemma":0.000009029688,"domain_scores_codex":[0.9959207,0.000514839,0.0004366786,0.001311635,0.0008556557,0.0009605064],"domain_scores_gemma":[0.997994,0.001250178,0.0001364303,0.0003390834,0.00005833953,0.0002219439],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001537202,0.001769423,0.0006430533,0.00003099371,0.000005492528,0.0003700215,0.00137654,0.0000108234,0.9803192,0.0005163804,0.008060716,0.005360131],"study_design_scores_gemma":[0.002491076,0.0004285538,0.000507124,0.00009432703,0.000001524506,0.00006778611,0.0002621803,0.0006422844,0.9780971,0.0001697694,0.01686574,0.000372489],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.98432,0.0001336735,0.00004515631,0.009530744,0.002051978,0.002861972,0.0001594224,0.0001306478,0.0007664378],"genre_scores_gemma":[0.985748,0.001978828,0.00005789694,0.00799023,0.0002442682,0.001241137,0.0000199025,0.0000581895,0.002661581],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008805019,"threshold_uncertainty_score":0.9999471,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06687796374337787,"score_gpt":0.3781795053533151,"score_spread":0.3113015416099372,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}