{"id":"W2048049311","doi":"10.1039/c1md00199j","title":"Development of second generation epigenetic agents","year":2011,"lang":"en","type":"article","venue":"MedChemComm","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Cancer Research","funders":"","keywords":"Epigenetics; Computational biology; Biology; Computer science; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001929726,0.00009719745,0.00009525226,0.00003365716,0.00004838802,0.000004303032,0.0001227306,0.00009230336,0.0002953389],"category_scores_gemma":[0.00002223484,0.0000968834,0.00004183429,0.00004876745,0.00002953183,0.000001809411,0.00004833001,0.00003359429,0.00001404342],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000008052158,"about_ca_system_score_gemma":0.00005442564,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000003908178,"about_ca_topic_score_gemma":0.0001222832,"domain_scores_codex":[0.9992929,0.00003052747,0.0002587853,0.0001846872,0.0001030286,0.0001300708],"domain_scores_gemma":[0.9995313,0.000002523248,0.00009450618,0.0002505902,0.00006628839,0.00005480779],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000008613675,0.00005945461,0.003137103,0.00001191311,0.00002596682,3.285859e-7,0.0005410487,0.000003548795,0.9842848,0.00002612844,0.0001658458,0.0117352],"study_design_scores_gemma":[0.0001800775,0.00005657686,0.02820166,0.000003406096,0.000006620089,4.173198e-7,0.00002838865,0.00002644106,0.9400393,0.00005224263,0.0312983,0.000106542],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9861056,0.0006358835,0.004553055,0.000004862648,0.0001296705,0.00009656822,0.000003422907,0.000004974941,0.008466022],"genre_scores_gemma":[0.97488,0.00004704942,0.02428224,0.00003621654,0.00008415841,0.0000145909,0.0001044425,0.00001452683,0.0005367274],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04424552,"threshold_uncertainty_score":0.395079,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06943027545734108,"score_gpt":0.2722752989882153,"score_spread":0.2028450235308742,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}