{"id":"W2048051408","doi":"10.1016/s0960-8966(02)00079-2","title":"Strategies for muscle-specific targeting of adenoviral gene transfer vectors","year":2002,"lang":"en","type":"review","venue":"Neuromuscular Disorders","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":13,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University; Montreal Neurological Institute and Hospital","funders":"Duchenne Parent Project; Deutsche Forschungsgemeinschaft","keywords":"Retargeting; Transduction (biophysics); Viral vector; Biology; Genetic enhancement; Adenoviridae; Vector (molecular biology); Skeletal muscle; Transgene; Dystrophin; Myocyte; Immunogenicity; Virology; Cell biology; Myogenesis; Receptor; Molecular biology; Gene; Immunology; Recombinant DNA; Genetics; Antibody; Anatomy; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008309935,0.001453052,0.00140229,0.001965755,0.0003894554,0.00113869,0.001563931,0.001447527,0.001856631],"category_scores_gemma":[0.0004597417,0.0004367572,0.0004965523,0.001576877,0.0009039018,0.001314037,0.0005915869,0.00253742,0.00206239],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001067479,"about_ca_system_score_gemma":0.000698442,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001302619,"about_ca_topic_score_gemma":0.001823041,"domain_scores_codex":[0.9997982,0.00002639457,0.00002035145,0.00004082737,0.00008986943,0.00002434881],"domain_scores_gemma":[0.9998612,0.00006751077,0.00001651166,0.00001027328,0.00003121325,0.00001316276],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001367009,0.0002103328,0.0001514872,0.007396437,0.00007880253,0.0007153963,0.0001520717,0.001342377,0.07070415,0.01935802,0.01444853,0.8853057],"study_design_scores_gemma":[0.0000679668,0.0001904753,0.0004461801,0.0008481351,0.0001026046,0.002690486,0.00005989075,0.000472133,0.04089352,0.004116188,0.950064,0.00004835747],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.001089148,0.9853535,0.00929586,0.0002662106,0.0005358711,0.00003637656,0.00003776462,0.00007169979,0.003313478],"genre_scores_gemma":[0.004280733,0.983539,0.007818214,0.0002407976,0.0001123222,0.00005698434,0.0001163378,0.00001453456,0.003821044],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.001965755,"threshold_uncertainty_score":0.007745087,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04150121915348182,"score_gpt":0.3088677693486701,"score_spread":0.2673665501951883,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}