{"id":"W2048065235","doi":"10.1016/j.actbio.2015.04.002","title":"A novel peptide for efficient siRNA delivery in vitro and therapeutics in vivo","year":2015,"lang":"en","type":"article","venue":"Acta Biomaterialia","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":21,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Waterloo","funders":"Natural Sciences and Engineering Research Council of Canada; Shanghai Jiao Tong University","keywords":"Small interfering RNA; Gene silencing; In vivo; RNA interference; In vitro; Cytotoxicity; Transfection; RNA; Vector (molecular biology); Cell biology; Molecular biology; Chemistry; Biology; Cancer research; Gene; Biochemistry; Biotechnology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001706184,0.0001243784,0.0001324941,0.00006526244,0.00001576147,0.00003721616,0.0001175945,0.0001207543,0.00000317585],"category_scores_gemma":[0.00001900423,0.0001146394,0.0000298176,0.00005321416,0.00004129856,0.000003981562,0.0000803601,0.00001965012,0.000002216751],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002023489,"about_ca_system_score_gemma":0.00004770689,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001791279,"about_ca_topic_score_gemma":0.0001033298,"domain_scores_codex":[0.9992678,0.00002158161,0.0001878224,0.0002503141,0.00005924795,0.0002132868],"domain_scores_gemma":[0.9996883,0.000006004883,0.00004456026,0.0001621448,0.00004796515,0.00005099839],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000660181,0.00007766279,0.0003574844,0.00001176307,0.00001417662,0.00000203398,0.000156281,0.000007209651,0.9978831,0.000004219718,0.0005725707,0.0002533026],"study_design_scores_gemma":[0.00143114,0.0002232833,0.0008844591,0.00001601991,0.000007701242,0.0000102431,0.0001545081,0.0004336104,0.9873593,0.00002034531,0.00929982,0.000159596],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9988285,0.0001748815,0.0001393515,0.0001118022,0.0003969641,0.0001948935,0.00008757825,0.00000586762,0.00006018542],"genre_scores_gemma":[0.9987896,0.00004445676,0.0005946644,0.0002455499,0.0001009548,0.00003080557,0.00005472843,0.00001430794,0.0001249013],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01052384,"threshold_uncertainty_score":0.4674861,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02979353505669756,"score_gpt":0.2696821937822372,"score_spread":0.2398886587255396,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}