{"id":"W2048065235","doi":"10.1016/j.actbio.2015.04.002","title":"A novel peptide for efficient siRNA delivery in vitro and therapeutics in vivo","year":2015,"lang":"en","type":"article","venue":"Acta Biomaterialia","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":21,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Waterloo","funders":"Natural Sciences and Engineering Research Council of Canada; Shanghai Jiao Tong University","keywords":"Small interfering RNA; Gene silencing; In vivo; RNA interference; In vitro; Cytotoxicity; Transfection; RNA; Vector (molecular biology); Cell biology; Molecular biology; Chemistry; Biology; Cancer research; Gene; Biochemistry; Biotechnology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002368745,0.0003382426,0.0002385078,0.0001217055,0.000180818,0.0002757015,0.0002753272,0.0005516856,0.001129627],"category_scores_gemma":[0.0001662466,0.0001232276,0.0001982834,0.0001063671,0.0002160788,0.0003684042,0.0002649518,0.0005181605,0.0004837808],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000222942,"about_ca_system_score_gemma":0.0003254017,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001451916,"about_ca_topic_score_gemma":0.0002178651,"domain_scores_codex":[0.9999129,0.0000123118,0.000008163879,0.0000210981,0.00002550284,0.00002009002],"domain_scores_gemma":[0.9999093,0.00001744553,0.00001778224,0.000008433737,0.00001643594,0.00003061714],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008536586,0.00002218071,0.00003779942,0.00008061977,0.000003213435,0.0001308593,0.00001137418,0.0001079445,0.9946247,0.0003774521,0.00007293377,0.004445554],"study_design_scores_gemma":[0.00006653107,0.0004997076,0.0004180626,0.000008867849,0.0000146774,0.0009521383,0.000007777962,0.0006284961,0.9886705,0.0001435726,0.008578182,0.00001148061],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8957703,0.009277363,0.08534568,0.0005945028,0.000403486,0.0003624027,0.0004049281,0.0003068563,0.007534462],"genre_scores_gemma":[0.9386117,0.003217448,0.05087341,0.0003919787,0.00008442128,0.0002093173,0.0003714223,0.00004659333,0.006193785],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001129627,"threshold_uncertainty_score":0.003778994,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02979353505669756,"score_gpt":0.2696821937822372,"score_spread":0.2398886587255396,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}