{"id":"W2048087817","doi":"10.1021/ol9019474","title":"Peptide Nucleic Acid Containing a Meta-Substituted Phenylpyrrolocytosine Exhibits a Fluorescence Response and Increased Binding Affinity toward RNA","year":2009,"lang":"en","type":"article","venue":"Organic Letters","topic":"DNA and Nucleic Acid Chemistry","field":"Biochemistry, Genetics and Molecular Biology","cited_by":34,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"","keywords":"Chemistry; Nucleic acid; Nucleobase; RNA; Peptide nucleic acid; DNA; Fluorescence; Peptide; Stereochemistry; Binding site; Biochemistry; Combinatorial chemistry; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0003998669,0.0003189717,0.0003479623,0.00005634739,0.0001574458,0.00006726796,0.0002833232,0.0001785109,0.0000911269],"category_scores_gemma":[0.0002914062,0.0002998431,0.0001333648,0.0001703139,0.0001418274,0.00001704065,0.0001209977,0.0002098717,0.0000175906],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004696969,"about_ca_system_score_gemma":0.00008743498,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000009569138,"about_ca_topic_score_gemma":0.000002257164,"domain_scores_codex":[0.9984256,0.0001191675,0.0002738621,0.0005670048,0.0001871982,0.0004271551],"domain_scores_gemma":[0.999154,0.00003526911,0.0001331424,0.0004263912,0.00004595421,0.0002052805],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001012536,0.00004191613,0.0001453143,0.00001277442,0.0002081849,0.00006358849,0.0001256561,0.00000104653,0.9968466,0.000005272886,0.001209592,0.0003275409],"study_design_scores_gemma":[0.001245922,0.0001876701,0.00213116,0.00002169541,0.0002509597,0.00009602473,0.0001004949,0.00001683806,0.9948293,0.000005451003,0.000761683,0.0003528092],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.995751,0.0003895297,0.0003302898,0.003158966,0.00005336666,0.0001447492,0.00001528675,0.00006544928,0.00009140905],"genre_scores_gemma":[0.994502,0.00005357671,0.001612759,0.003555228,0.0001420501,0.000008841649,0.00005946669,0.00003482219,0.0000312501],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002017285,"threshold_uncertainty_score":0.9999453,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01522961088817406,"score_gpt":0.2251808680917787,"score_spread":0.2099512572036046,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}