{"id":"W2048087817","doi":"10.1021/ol9019474","title":"Peptide Nucleic Acid Containing a Meta-Substituted Phenylpyrrolocytosine Exhibits a Fluorescence Response and Increased Binding Affinity toward RNA","year":2009,"lang":"en","type":"article","venue":"Organic Letters","topic":"DNA and Nucleic Acid Chemistry","field":"Biochemistry, Genetics and Molecular Biology","cited_by":34,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"","keywords":"Chemistry; Nucleic acid; Nucleobase; RNA; Peptide nucleic acid; DNA; Fluorescence; Peptide; Stereochemistry; Binding site; Biochemistry; Combinatorial chemistry; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001617493,0.0003240427,0.0002154957,0.0001062931,0.0001327521,0.0001940939,0.0001812976,0.0004298888,0.0008921177],"category_scores_gemma":[0.0002061385,0.0001953878,0.0001219765,0.0001016652,0.0002588898,0.0001399333,0.0001304935,0.0004391772,0.000302827],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001872323,"about_ca_system_score_gemma":0.000122439,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004490994,"about_ca_topic_score_gemma":0.0008531205,"domain_scores_codex":[0.9998523,0.0000268928,0.000006610192,0.00004632535,0.00003946744,0.00002844712],"domain_scores_gemma":[0.9997804,0.00008288374,0.00004602483,0.00001780631,0.00002743549,0.00004559743],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000007473341,0.000001099629,0.00001563088,0.000007993987,6.691675e-7,0.00001186074,0.000003492315,0.00001299547,0.9997811,0.00001639886,0.000001996181,0.0001392819],"study_design_scores_gemma":[0.000002045573,0.00007681545,0.0005559442,0.000001103181,0.000003550968,0.00009071006,0.000005290337,0.0001766133,0.9987183,0.000007097126,0.0003604916,0.00000203402],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9919392,0.0009005085,0.005516228,0.00006365785,0.00001674413,0.00001617197,0.00006563517,0.00006553897,0.001416145],"genre_scores_gemma":[0.9905815,0.0004241774,0.007253222,0.00004964324,0.000007887393,0.00001979429,0.0001160756,0.00001938559,0.001528329],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008921177,"threshold_uncertainty_score":0.002984464,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01522961088817406,"score_gpt":0.2251808680917787,"score_spread":0.2099512572036046,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}