{"id":"W2048088501","doi":"10.1371/journal.ppat.1002840","title":"CD160 and PD-1 Co-Expression on HIV-Specific CD8 T Cells Defines a Subset with Advanced Dysfunction","year":2012,"lang":"en","type":"article","venue":"PLoS Pathogens","topic":"Immune Cell Function and Interaction","field":"Immunology and Microbiology","cited_by":143,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Royal Victoria Hospital; McGill University Health Centre; Royal Victoria Regional Health Centre; Université de Montréal; Caprion (Canada)","funders":"National Institutes of Health; National Institute of Allergy and Infectious Diseases; Canadian Institutes of Health Research; Canadian Foundation for AIDS Research; Styrelsen för Internationellt Utvecklingssamarbete","keywords":"Cytotoxic T cell; CD8; Downregulation and upregulation; T cell; Biology; Cell biology; Immunology; Jurkat cells; Chemistry; Immune system; In vitro; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":["insufficient_payload"],"category_scores_codex":[0.0001020482,0.0002219349,0.0002151387,0.0001231606,0.0002558694,0.00001770418,0.00006031942,0.0001824978,0.001439219],"category_scores_gemma":[0.00001918814,0.0001680422,0.00005155212,0.00009112363,0.00008188262,0.0002436233,0.00002440752,0.0002807144,0.002854529],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004351609,"about_ca_system_score_gemma":0.00001050672,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000002543228,"about_ca_topic_score_gemma":0.000001057125,"domain_scores_codex":[0.998956,0.0001365126,0.0002039499,0.0002902959,0.00005433655,0.0003588729],"domain_scores_gemma":[0.9994045,0.0000972385,0.0001242002,0.0002681603,0.00006398523,0.00004185498],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001006427,0.0003171052,0.004532353,0.00001505378,0.00004417111,0.00000178763,0.0003494435,0.000006706205,0.9804083,0.00007968295,0.01147248,0.001766501],"study_design_scores_gemma":[0.001171894,0.0004575994,0.007160316,0.00007454483,0.00003597546,0.00005108264,0.0003986595,0.000003528301,0.8028172,0.000002779779,0.1876138,0.0002126464],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9913967,0.001329402,0.0002611468,0.00007076225,0.00196895,0.0002658979,0.00002532921,0.0001285919,0.004553171],"genre_scores_gemma":[0.9931481,0.0003997465,0.0001305096,0.0002276438,0.00008900741,0.00004472607,0.0003660497,0.00003191303,0.005562307],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1775911,"threshold_uncertainty_score":0.9994736,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0156888731888444,"score_gpt":0.2119063357760294,"score_spread":0.196217462587185,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}