{"id":"W2048194629","doi":"10.1021/ja800140g","title":"Site-Specific Prodrug Release Using Visible Light","year":2008,"lang":"en","type":"article","venue":"Journal of the American Chemical Society","topic":"Photodynamic Therapy Research Studies","field":"Medicine","cited_by":81,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Photosensitizer; Chemistry; Prodrug; Singlet oxygen; Dioxetane; Photodynamic therapy; Photochemistry; Visible spectrum; Verteporfin; Chlorin; Combinatorial chemistry; Chemiluminescence; Oxygen; Organic chemistry; Optoelectronics; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000264641,0.0001421646,0.0004925715,0.00002449719,0.0001782623,0.00001000454,0.0002665477,0.00003565496,0.00003284287],"category_scores_gemma":[0.0001779331,0.00008190754,0.0007073765,0.0004900123,0.0006944631,0.0000574138,0.0001386303,0.0007131782,0.000004912498],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000438788,"about_ca_system_score_gemma":0.000216521,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002491271,"about_ca_topic_score_gemma":1.909706e-7,"domain_scores_codex":[0.9984465,0.00005218211,0.0003582838,0.0001462815,0.0006843625,0.0003124316],"domain_scores_gemma":[0.9987009,0.0001024403,0.000458524,0.0002944839,0.0002508883,0.000192796],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002938324,0.000168322,0.003432673,0.0000158903,0.0001836738,0.00003689578,0.0008739975,0.000007967867,0.9652107,9.459793e-7,0.02933256,0.0004425173],"study_design_scores_gemma":[0.00210152,0.0003718443,0.01175343,0.0002197811,0.0001323577,0.002351115,0.0009050508,0.00053085,0.9507354,0.0000808348,0.03057349,0.0002442666],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.993659,0.0007849358,0.00003817366,0.005124431,0.0000725423,0.0001392685,0.000003087062,0.00001487852,0.0001636342],"genre_scores_gemma":[0.992503,0.001738258,0.003747413,0.001160006,0.0005049057,0.000001544998,4.374205e-7,0.00002416979,0.0003202145],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01447526,"threshold_uncertainty_score":0.3340093,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0255833438333588,"score_gpt":0.3066902426373382,"score_spread":0.2811068988039794,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}