{"id":"W2048213202","doi":"10.1038/emboj.2008.193","title":"DNA methylation in ES cells requires the lysine methyltransferase G9a but not its catalytic activity","year":2008,"lang":"en","type":"article","venue":"The EMBO Journal","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":229,"is_retracted":false,"has_abstract":false,"ca_institutions":"BC Cancer Agency; University of British Columbia","funders":"Canadian Institutes of Health Research; European Commission; Michael Smith Health Research BC; Novartis Foundation","keywords":"Biology; DNA methylation; RNA-Directed DNA Methylation; Histone methylation; Epigenomics; Methylation; Epigenetics of physical exercise; Retrotransposon; EZH2; Histone methyltransferase; Methyltransferase; Molecular biology; Epigenetics; Genetics; DNA; Gene; Transposable element; Gene expression","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002388373,0.0003218272,0.0003218251,0.0002783938,0.0001708563,0.0007178095,0.0003501486,0.0004663786,0.001372607],"category_scores_gemma":[0.0003139823,0.0003384055,0.0003088544,0.0002033502,0.000384215,0.0003780471,0.0003780531,0.0009981256,0.001600359],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004021184,"about_ca_system_score_gemma":0.0003010141,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008532058,"about_ca_topic_score_gemma":0.001222265,"domain_scores_codex":[0.9998191,0.00002707053,0.0000221526,0.00005684233,0.00004713545,0.00002773436],"domain_scores_gemma":[0.9997469,0.00005178552,0.00004711637,0.0000720594,0.00002593364,0.00005628103],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008439358,0.000005572229,0.000360565,0.00001282025,0.00000729379,0.00006069275,0.000008265072,0.0000390824,0.997615,0.0003000897,0.00006121908,0.001445087],"study_design_scores_gemma":[0.00001296391,0.00002945163,0.004737199,0.000003476658,0.00001113064,0.0001822936,0.00001568734,0.0005789351,0.9909716,0.0002491102,0.003203926,0.000004166177],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.97846,0.00316436,0.01117257,0.0006541346,0.0002085817,0.00001604071,0.001487462,0.0004672678,0.004369609],"genre_scores_gemma":[0.9874483,0.000906291,0.003147492,0.0001279083,0.00001759034,0.00001248977,0.001629755,0.0001198919,0.006590374],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001372607,"threshold_uncertainty_score":0.004591823,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03074676035920127,"score_gpt":0.2731381848689598,"score_spread":0.2423914245097585,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}