{"id":"W2048213202","doi":"10.1038/emboj.2008.193","title":"DNA methylation in ES cells requires the lysine methyltransferase G9a but not its catalytic activity","year":2008,"lang":"en","type":"article","venue":"The EMBO Journal","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":229,"is_retracted":false,"has_abstract":false,"ca_institutions":"BC Cancer Agency; University of British Columbia","funders":"Canadian Institutes of Health Research; European Commission; Michael Smith Health Research BC; Novartis Foundation","keywords":"Biology; DNA methylation; RNA-Directed DNA Methylation; Histone methylation; Epigenomics; Methylation; Epigenetics of physical exercise; Retrotransposon; EZH2; Histone methyltransferase; Methyltransferase; Molecular biology; Epigenetics; Genetics; DNA; Gene; Transposable element; Gene expression","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001139206,0.0001585162,0.0001602362,0.00006138358,0.0003689273,0.00004478799,0.0002970744,0.00009429525,0.00002217469],"category_scores_gemma":[0.0001558659,0.00009495236,0.0001300974,0.0001262171,0.0001100737,0.00001442502,0.00005064025,0.000310344,0.00001163813],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002848335,"about_ca_system_score_gemma":0.0001095679,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004187217,"about_ca_topic_score_gemma":0.00006908907,"domain_scores_codex":[0.9986145,0.0003870951,0.0002916364,0.0001947773,0.0002601943,0.0002517751],"domain_scores_gemma":[0.9992544,0.0001042107,0.0001432761,0.0003219746,0.0001059833,0.00007012651],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001078457,0.00004548979,0.0001928179,0.000004309352,0.00004121366,0.00001057814,0.0002665439,0.001470578,0.9930525,0.00003488068,0.00006242874,0.00471079],"study_design_scores_gemma":[0.0004242091,0.0001108077,0.009356671,0.000008036086,0.00003566614,0.0000576876,0.00005287253,0.000428484,0.9876202,0.0003332446,0.001442235,0.0001299047],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9927676,0.001728172,0.003418328,0.001312877,0.0002421385,0.0001619601,0.000009946375,0.000005054828,0.0003538943],"genre_scores_gemma":[0.9963884,0.002463688,0.0001117727,0.0001398659,0.0004490418,0.000006692203,0.00001049268,0.00001917281,0.0004108656],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.009163853,"threshold_uncertainty_score":0.3872045,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03074676035920127,"score_gpt":0.2731381848689598,"score_spread":0.2423914245097585,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}