{"id":"W2048244406","doi":"10.1021/jm0603668","title":"Discovery of a Potent and Selective Prostaglandin D<sub>2</sub> Receptor Antagonist, [(3<i>R</i>)-4-(4-Chloro- benzyl)-7-fluoro-5-(methylsulfonyl)-1,2,3,4-tetrahydrocyclopenta[<i>b</i>]indol-3-yl]-acetic Acid (MK-0524)","year":2007,"lang":"en","type":"article","venue":"Journal of Medicinal Chemistry","topic":"Inflammatory mediators and NSAID effects","field":"Medicine","cited_by":170,"is_retracted":false,"has_abstract":true,"ca_institutions":"Merck Canada Inc. (Canada)","funders":"","keywords":"Chemistry; Antagonist; Pharmacokinetics; Cmax; Pharmacology; Prostaglandin; Receptor antagonist; Stereochemistry; Receptor; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001124498,0.0003505514,0.0004550894,0.0001685193,0.0001209795,0.0004238751,0.000330131,0.0003699785,0.001153307],"category_scores_gemma":[0.0001680885,0.0001614048,0.0001812843,0.0001777931,0.000193508,0.0001962698,0.0002200704,0.0005393534,0.001072672],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003205812,"about_ca_system_score_gemma":0.000495796,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006562572,"about_ca_topic_score_gemma":0.001479983,"domain_scores_codex":[0.9999163,0.00001226099,0.000006302902,0.00001503062,0.00002459587,0.00002547269],"domain_scores_gemma":[0.9999565,0.000004083657,0.00001121314,0.000003559384,0.0000100784,0.00001455463],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002858435,0.00007194061,0.0002405262,0.0001407966,0.00001955264,0.0002178728,0.00002610981,0.0004847498,0.9770162,0.0007947516,0.0007055854,0.01999618],"study_design_scores_gemma":[0.0001859256,0.003086233,0.002127006,0.00001881152,0.00006957703,0.001191692,0.00002932356,0.001679968,0.947277,0.0002462599,0.04405794,0.00003037694],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9256136,0.0281894,0.02866757,0.00107178,0.000291644,0.0003747344,0.001487944,0.0004382084,0.01386512],"genre_scores_gemma":[0.9511935,0.01775821,0.0169118,0.0004641623,0.0001504515,0.000154255,0.001749696,0.00004496741,0.01157297],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001153307,"threshold_uncertainty_score":0.003858268,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005476983492273665,"score_gpt":0.2340464559640616,"score_spread":0.2285694724717879,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}