{"id":"W2048244406","doi":"10.1021/jm0603668","title":"Discovery of a Potent and Selective Prostaglandin D<sub>2</sub> Receptor Antagonist, [(3<i>R</i>)-4-(4-Chloro- benzyl)-7-fluoro-5-(methylsulfonyl)-1,2,3,4-tetrahydrocyclopenta[<i>b</i>]indol-3-yl]-acetic Acid (MK-0524)","year":2007,"lang":"en","type":"article","venue":"Journal of Medicinal Chemistry","topic":"Inflammatory mediators and NSAID effects","field":"Medicine","cited_by":170,"is_retracted":false,"has_abstract":true,"ca_institutions":"Merck Canada Inc. (Canada)","funders":"","keywords":"Chemistry; Antagonist; Pharmacokinetics; Cmax; Pharmacology; Prostaglandin; Receptor antagonist; Stereochemistry; Receptor; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.002575664,0.0005636847,0.001455966,0.0002523616,0.000149812,0.00004073714,0.0002763529,0.0004031066,0.00003459463],"category_scores_gemma":[0.0008868374,0.0004435055,0.0003782939,0.0004648875,0.0005164325,0.0003387207,0.0001033941,0.001439254,0.000007208907],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004608879,"about_ca_system_score_gemma":0.000675151,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001671003,"about_ca_topic_score_gemma":0.000005317688,"domain_scores_codex":[0.9954821,0.00009433879,0.001645665,0.0004821004,0.001522472,0.0007733572],"domain_scores_gemma":[0.9965283,0.0003722281,0.001374692,0.0003896895,0.0005430123,0.0007920761],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.005279,0.0004270378,0.01534113,0.001522265,0.0003554787,0.001225343,0.0007625734,0.000001560164,0.9671656,0.000005789831,0.001365886,0.006548296],"study_design_scores_gemma":[0.006839105,0.001653139,0.01228282,0.00196531,0.0005851917,0.004553131,0.001034093,0.00001412132,0.9698464,0.00005013449,0.0007939101,0.0003826962],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.991532,0.005112793,0.0004343638,0.0004414699,0.0006929375,0.0005253381,0.00002896408,0.00002788788,0.001204302],"genre_scores_gemma":[0.9955329,0.001513071,0.000509069,0.0002710842,0.001915661,0.000008864014,0.00002304814,0.00007378841,0.0001525582],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006165599,"threshold_uncertainty_score":0.9998017,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005476983492273665,"score_gpt":0.2340464559640616,"score_spread":0.2285694724717879,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}