{"id":"W2048277557","doi":"10.1021/bc060205i","title":"Biologically Active Amphotericin B-Calix[4]arene Conjugates","year":2006,"lang":"ca","type":"article","venue":"Bioconjugate Chemistry","topic":"Molecular Junctions and Nanostructures","field":"Engineering","cited_by":49,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Chemistry; Amphotericin B; Conjugate; Tetramer; Liposome; Stereochemistry; Covalent bond; Monomer; Lipid bilayer; Antifungal; Biochemistry; Membrane; Organic chemistry; Enzyme","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.000100228,0.0007353876,0.0005999763,0.00006614404,0.0002185642,0.000178294,0.0004071957,0.0007686262,0.00260349],"category_scores_gemma":[0.00005264554,0.0006927678,0.0003315916,0.0003764519,0.0003097372,0.00009488798,0.0001457339,0.0005078759,0.000227121],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002212466,"about_ca_system_score_gemma":0.00008384757,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004607467,"about_ca_topic_score_gemma":0.00001124432,"domain_scores_codex":[0.9974147,0.00004672641,0.0006694015,0.000789095,0.0002605989,0.0008194793],"domain_scores_gemma":[0.9987206,0.00006667618,0.0001828265,0.0006674568,0.0001369527,0.0002254693],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008479936,0.00009477147,0.0001987802,0.000315194,0.0001687566,0.0001289796,0.00002302019,0.000543269,0.9890977,0.000286066,0.00757443,0.001484241],"study_design_scores_gemma":[0.000974983,0.00005551131,0.002243211,0.0001163845,0.0001185893,0.0000878827,0.00007247563,0.0004944588,0.929643,0.001493023,0.06381554,0.0008848921],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9569957,0.004377527,0.0006413076,0.0002581273,0.0008698718,0.0003888512,0.0006729881,0.0004932509,0.03530243],"genre_scores_gemma":[0.9944928,0.0004621059,0.0007048163,0.0001653902,0.001259611,0.00004786622,0.0006117389,0.0001025727,0.002153086],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05945464,"threshold_uncertainty_score":0.9995524,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004906435802229471,"score_gpt":0.1897138450050359,"score_spread":0.1848074092028064,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}