{"id":"W2048277557","doi":"10.1021/bc060205i","title":"Biologically Active Amphotericin B-Calix[4]arene Conjugates","year":2006,"lang":"ca","type":"article","venue":"Bioconjugate Chemistry","topic":"Molecular Junctions and Nanostructures","field":"Engineering","cited_by":49,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Chemistry; Amphotericin B; Conjugate; Tetramer; Liposome; Stereochemistry; Covalent bond; Monomer; Lipid bilayer; Antifungal; Biochemistry; Membrane; Organic chemistry; Enzyme","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001698034,0.0003415514,0.000258373,0.0001486447,0.0001570873,0.0003579671,0.0002166853,0.0003679524,0.00127818],"category_scores_gemma":[0.0002405954,0.0001398182,0.0001301051,0.0001501863,0.0002496144,0.0003670293,0.0002216817,0.0004700242,0.0003154553],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003131283,"about_ca_system_score_gemma":0.0001887598,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001926833,"about_ca_topic_score_gemma":0.0003455366,"domain_scores_codex":[0.9998912,0.00002665462,0.000008805172,0.00002120205,0.00003211979,0.00002004548],"domain_scores_gemma":[0.999864,0.00003400905,0.00004480828,0.0000157237,0.00002048589,0.00002095325],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004710648,0.00002360724,0.00004556264,0.00003534895,0.000003912748,0.00003707419,0.00001232463,0.0002000541,0.9976496,0.0003698319,0.0000239577,0.001551677],"study_design_scores_gemma":[0.00001863201,0.0002323993,0.0002214499,0.000002939702,0.000008579496,0.0001133756,0.000005839715,0.000345521,0.9958055,0.00005970847,0.003182224,0.000003758334],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9832496,0.002163456,0.0109232,0.0001325779,0.00004304438,0.0001098716,0.0001186366,0.00007769306,0.003181819],"genre_scores_gemma":[0.9807192,0.00152648,0.01281878,0.00008325366,0.00001541404,0.0001032238,0.0002278753,0.000018528,0.004487247],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00127818,"threshold_uncertainty_score":0.004275978,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004906435802229471,"score_gpt":0.1897138450050359,"score_spread":0.1848074092028064,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}