{"id":"W2048285147","doi":"10.1016/j.clinthera.2009.11.012","title":"Effect of the CYP3A inhibitor ketoconazole on the pharmacokinetics and pharmacodynamics of bortezomib in patients with advanced solid tumors: A prospective, multicenter, open-label, randomized, two-way crossover drug—drug interaction study","year":2009,"lang":"en","type":"article","venue":"Clinical Therapeutics","topic":"Ubiquitin and proteasome pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":62,"is_retracted":false,"has_abstract":false,"ca_institutions":"Princess Margaret Cancer Centre","funders":"Takeda Oncology","keywords":"Medicine; Bortezomib; Pharmacokinetics; Ketoconazole; Pharmacology; Pharmacodynamics; Concomitant; Crossover study; Adverse effect; Internal medicine; Multiple myeloma; Placebo; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001544011,0.0002560037,0.0005954047,0.00002762615,0.00007533233,0.00003486648,0.0004196357,0.00006513897,0.000005177529],"category_scores_gemma":[0.000179075,0.000136423,0.0001081097,0.0001293899,0.0003342371,0.00001500774,0.0002019183,0.0003930505,5.993074e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001897365,"about_ca_system_score_gemma":0.00003980744,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00000531076,"about_ca_topic_score_gemma":0.000008765606,"domain_scores_codex":[0.997291,0.001141984,0.0007563719,0.000377709,0.0002266046,0.0002063545],"domain_scores_gemma":[0.9982887,0.0005611363,0.0005342035,0.000405343,0.0001598295,0.00005078887],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.564307,0.01487035,0.2640666,0.0001188201,0.00105642,0.000003720372,0.001400341,0.0005154245,0.09516547,0.0001059255,0.00006679119,0.05832319],"study_design_scores_gemma":[0.4400961,0.008980859,0.02784718,0.0003125402,0.0003470177,0.000001208141,0.0001647565,0.003481612,0.5180501,0.00009125201,0.0002486152,0.0003787229],"study_design_candidate":"randomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.993971,0.0001219756,0.00001805866,0.0001095582,0.0002134764,0.005347041,0.00003500451,0.000005763814,0.00017811],"genre_scores_gemma":[0.9988476,0.0001393673,0.00006768724,0.0006717871,0.00007232189,0.000125331,0.00001018972,0.00002427014,0.00004144186],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4228846,"threshold_uncertainty_score":0.5563167,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01977489595929071,"score_gpt":0.3770323509474527,"score_spread":0.357257454988162,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}