{"id":"W2048285147","doi":"10.1016/j.clinthera.2009.11.012","title":"Effect of the CYP3A inhibitor ketoconazole on the pharmacokinetics and pharmacodynamics of bortezomib in patients with advanced solid tumors: A prospective, multicenter, open-label, randomized, two-way crossover drug—drug interaction study","year":2009,"lang":"en","type":"article","venue":"Clinical Therapeutics","topic":"Ubiquitin and proteasome pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":62,"is_retracted":false,"has_abstract":false,"ca_institutions":"Princess Margaret Cancer Centre","funders":"Takeda Oncology","keywords":"Medicine; Bortezomib; Pharmacokinetics; Ketoconazole; Pharmacology; Pharmacodynamics; Concomitant; Crossover study; Adverse effect; Internal medicine; Multiple myeloma; Placebo; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002387976,0.002105579,0.003710557,0.0005432043,0.0006855956,0.001294025,0.0007640936,0.001873231,0.002034432],"category_scores_gemma":[0.003501144,0.001199274,0.002131533,0.0007333988,0.002311514,0.001807198,0.0004547973,0.003689258,0.0005135175],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00103871,"about_ca_system_score_gemma":0.001016713,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008546611,"about_ca_topic_score_gemma":0.00124172,"domain_scores_codex":[0.9977798,0.001222965,0.0001376076,0.0003804709,0.0001760082,0.000303163],"domain_scores_gemma":[0.9968919,0.001028701,0.0006910017,0.0003959359,0.0001179144,0.0008745353],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9742527,0.008652865,0.003192465,0.00007089075,0.0007339398,0.00004394367,0.00005672244,0.0004378091,0.003906506,0.0000448536,0.0002137824,0.008393602],"study_design_scores_gemma":[0.5719415,0.3970002,0.02433541,0.00001209204,0.001289951,0.000142617,0.00005315393,0.001527174,0.002925657,0.0001829211,0.000522488,0.00006687234],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9984573,0.0005531633,0.0001839313,0.0001102348,0.0000704999,0.0001816725,0.0001799966,0.00002506986,0.0002380454],"genre_scores_gemma":[0.9984028,0.000276997,0.0002843693,0.0001743884,0.0001380414,0.0001572095,0.0002271447,0.00001329474,0.0003257212],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003710557,"threshold_uncertainty_score":0.01262897,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01977489595929071,"score_gpt":0.3770323509474527,"score_spread":0.357257454988162,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}