{"id":"W2048296559","doi":"10.1002/path.2903","title":"Using mouse models to investigate the biological and physiological consequences of defects in the Fanconi anaemia/breast cancer DNA repair signalling pathway","year":2011,"lang":"en","type":"letter","venue":"The Journal of Pathology","topic":"DNA Repair Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; McGill Genome Centre; Jewish General Hospital; McGill University Health Centre","funders":"Ministero dello Sviluppo Economico; Jewish General Hospital","keywords":"PALB2; DNA repair; Biology; Fanconi anemia; Breast cancer; Gene; Cancer research; Genetics; Heterozygote advantage; Phenotype; Cancer; DNA damage; Mutation; Germline mutation; DNA; Allele","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00161133,0.0007470581,0.0005681767,0.0002785202,0.0004867977,0.0009941605,0.0007100899,0.007684713,0.002039444],"category_scores_gemma":[0.002325435,0.0002414926,0.0005667112,0.0002178458,0.001157706,0.0008641956,0.0005337513,0.00565397,0.00205239],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007820655,"about_ca_system_score_gemma":0.000225787,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002541797,"about_ca_topic_score_gemma":0.000523072,"domain_scores_codex":[0.999206,0.0003151043,0.00007216858,0.0001016322,0.0002306621,0.00007453889],"domain_scores_gemma":[0.9986567,0.0007455311,0.0002048489,0.0001345016,0.0001448932,0.0001134226],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002048756,0.0008030848,0.004896672,0.001683585,0.0002642808,0.06036416,0.0005460614,0.0007283107,0.2119024,0.03854785,0.5108973,0.1673177],"study_design_scores_gemma":[0.001317756,0.002282897,0.004975349,0.0005141975,0.0002760548,0.09363051,0.000280475,0.003246356,0.05926318,0.02051596,0.8135548,0.0001425059],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"commentary","genre_gemma":"empirical","genre_scores_codex":[0.07644906,0.04999925,0.02341153,0.7660519,0.04137847,0.0005476929,0.0008406924,0.001345021,0.03997632],"genre_scores_gemma":[0.324443,0.0779885,0.02355557,0.4783108,0.036635,0.00139859,0.0007685042,0.0002655867,0.05663452],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.007684713,"threshold_uncertainty_score":0.008521676,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09863245447651377,"score_gpt":0.2823714572975623,"score_spread":0.1837390028210485,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}