{"id":"W2048310708","doi":"10.2174/1566523024605609","title":"Intracellular Barriers to Non-Viral Gene Transfer","year":2002,"lang":"en","type":"review","venue":"Current Gene Therapy","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":201,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children; University of Toronto; SickKids Foundation","funders":"Medical Research Council; Vanderbilt University; Cystic Fibrosis Foundation","keywords":"Biology; Gene delivery; Plasmid; Naked DNA; Cell biology; Transgene; Genetic enhancement; DNA; Viral vector; Cytoplasm; Transfection; Gene; Genetics; Recombinant DNA","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001666634,0.0007375898,0.001037155,0.0001648066,0.0001129285,0.00006038063,0.0008091145,0.0004644304,0.0004211445],"category_scores_gemma":[0.00001457872,0.0006260693,0.0008540481,0.0001897396,0.00006561012,0.000004589136,0.00009044674,0.0003380488,0.0004394288],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004314464,"about_ca_system_score_gemma":0.0002790208,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000004081525,"about_ca_topic_score_gemma":0.000001720986,"domain_scores_codex":[0.9975067,0.0001420402,0.0006033648,0.0009452524,0.0002251908,0.0005774306],"domain_scores_gemma":[0.9984272,0.000007730665,0.00009033488,0.0009113635,0.00008851934,0.0004749152],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00003732473,0.000072251,0.000001843277,0.0004126412,0.0002831268,0.000007041482,0.00009167259,0.00000603669,0.02466891,0.00000195386,0.007930495,0.9664867],"study_design_scores_gemma":[0.0003444316,0.0005011691,5.931381e-7,0.0005725981,0.000130788,0.00002214575,0.000005903232,0.000003669488,0.04559968,0.000003690927,0.9520984,0.0007169648],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.01057227,0.9850916,0.001656877,0.00001690927,0.001409277,0.0009508493,0.0001814337,0.00002186534,0.00009896112],"genre_scores_gemma":[0.0006247922,0.9957088,0.00007802586,0.0002040651,0.001486092,0.000249522,0.0008292876,0.0001215973,0.0006977897],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9657698,"threshold_uncertainty_score":0.9996191,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04388614453587219,"score_gpt":0.3164696479299677,"score_spread":0.2725835033940955,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}