{"id":"W2048310708","doi":"10.2174/1566523024605609","title":"Intracellular Barriers to Non-Viral Gene Transfer","year":2002,"lang":"en","type":"review","venue":"Current Gene Therapy","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":201,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children; University of Toronto; SickKids Foundation","funders":"Medical Research Council; Vanderbilt University; Cystic Fibrosis Foundation","keywords":"Biology; Gene delivery; Plasmid; Naked DNA; Cell biology; Transgene; Genetic enhancement; DNA; Viral vector; Cytoplasm; Transfection; Gene; Genetics; Recombinant DNA","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005622507,0.0005603293,0.000778439,0.0006223022,0.0003953266,0.002092369,0.0005648335,0.001583833,0.002647146],"category_scores_gemma":[0.0005553881,0.0002581691,0.0005719218,0.000358871,0.0007386129,0.001201127,0.0009993769,0.00168319,0.001944922],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009510938,"about_ca_system_score_gemma":0.0008194275,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005117474,"about_ca_topic_score_gemma":0.0003805112,"domain_scores_codex":[0.99931,0.0001309675,0.00005192857,0.00009736208,0.0003139735,0.0000956582],"domain_scores_gemma":[0.9996024,0.0001600122,0.00008827071,0.00002366419,0.00009509877,0.00003058813],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001457966,0.00009551195,0.0008793106,0.01095529,0.0001011173,0.001964234,0.0008435072,0.001337213,0.601981,0.1049295,0.01111753,0.26565],"study_design_scores_gemma":[0.00001982752,0.0004225751,0.00147497,0.0012578,0.0001139704,0.004757175,0.0004006248,0.001038187,0.2101377,0.01507268,0.7652575,0.00004699669],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.03355446,0.8534365,0.07397621,0.003653964,0.001293422,0.0002418177,0.0002869986,0.0004830027,0.03307357],"genre_scores_gemma":[0.2232763,0.7008056,0.03071218,0.002754607,0.0009910979,0.0005998467,0.0007039487,0.0001661622,0.03999029],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002647146,"threshold_uncertainty_score":0.008855522,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04388614453587219,"score_gpt":0.3164696479299677,"score_spread":0.2725835033940955,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}