{"id":"W2048311980","doi":"10.1371/journal.pone.0056567","title":"Loss of lkb1 Expression Reduces the Latency of ErbB2-Mediated Mammary Gland Tumorigenesis, Promoting Changes in Metabolic Pathways","year":2013,"lang":"en","type":"article","venue":"PLoS ONE","topic":"PI3K/AKT/mTOR signaling in cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":37,"is_retracted":false,"has_abstract":true,"ca_institutions":"Dalhousie University","funders":"Faculty of Medicine, Dalhousie University; Canadian Institutes of Health Research; Dalhousie University; Dalhousie Medical Research Foundation; Beatrice Hunter Cancer Research Institute; Nova Scotia Health Research Foundation; Cancer Research Institute","keywords":"mTORC2; PI3K/AKT/mTOR pathway; mTORC1; Carcinogenesis; Biology; Cancer research; STK11; RHEB; AMPK; Mechanistic target of rapamycin; Protein kinase B; RPTOR; Signal transduction; Kinase; Cell biology; Cancer; Protein kinase A; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0000904869,0.0003395084,0.0002554834,0.0002741563,0.0001303212,0.0002810286,0.0001667975,0.0002403379,0.001761082],"category_scores_gemma":[0.00009844547,0.0001862906,0.0001714958,0.0001461095,0.0001768274,0.0001775084,0.000153875,0.0005711094,0.0004125465],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003604004,"about_ca_system_score_gemma":0.0002497566,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006376308,"about_ca_topic_score_gemma":0.001484084,"domain_scores_codex":[0.9998726,0.00001677053,0.00001866078,0.00002603397,0.00002757241,0.00003838541],"domain_scores_gemma":[0.9998558,0.00001701408,0.00004915319,0.00001047575,0.00001081035,0.0000567256],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002473129,0.00005139342,0.0002784315,0.0000280639,0.000004137921,0.00002213355,0.000007698694,0.00004221871,0.9983859,0.00004646504,0.00005578682,0.0008304265],"study_design_scores_gemma":[0.0000343234,0.0007462866,0.01111867,0.000009567365,0.00002663978,0.0003371509,0.00005186654,0.0007855459,0.983923,0.000045231,0.002915558,0.000006167642],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9955798,0.001273063,0.0007988633,0.0001539126,0.00002887889,0.0000202832,0.0006442665,0.0001060329,0.00139489],"genre_scores_gemma":[0.9937218,0.0008632101,0.001041791,0.00005988083,0.000009539185,0.00004369034,0.0008120166,0.00003478756,0.00341316],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001761082,"threshold_uncertainty_score":0.005891383,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0243999295941644,"score_gpt":0.2182708599658028,"score_spread":0.1938709303716384,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}