{"id":"W2048323857","doi":"10.1107/s2053230x14000144","title":"The structure of human tau-tubulin kinase 1 both in the apo form and in complex with an inhibitor","year":2014,"lang":"en","type":"article","venue":"Acta Crystallographica Section F Structural Biology Communications","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":28,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Basic Energy Sciences; National Research Council Canada; Western Economic Diversification Canada; Natural Sciences and Engineering Research Council of Canada; Office of Science; University of Saskatchewan; Canadian Light Source; Canadian Institutes of Health Research; Industrial Macromolecular Crystallography Association Collaborative Access Team; U.S. Department of Energy","keywords":"Casein kinase 2; Cyclin-dependent kinase 9; MAP2K7; Mitogen-activated protein kinase kinase; MAP kinase kinase kinase; Kinase; Cyclin-dependent kinase 2; Casein kinase 2, alpha 1; Protein kinase domain; ASK1; Biology; Cell biology; Biochemistry; Chemistry; Protein kinase A; Molecular biology; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002191968,0.0006143905,0.0007522295,0.0003843307,0.0006837255,0.0007110599,0.001363573,0.0006635228,0.00201564],"category_scores_gemma":[0.0003868948,0.0004357666,0.0003666846,0.0006936008,0.0003924163,0.0004298919,0.0001593199,0.001287047,0.0003868275],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001976474,"about_ca_system_score_gemma":0.0006864553,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.007818651,"about_ca_topic_score_gemma":0.005710911,"domain_scores_codex":[0.9998097,0.00002083892,0.00000967972,0.0000486272,0.00006849959,0.00004264247],"domain_scores_gemma":[0.9998011,0.00005154491,0.00005868783,0.00001217653,0.00002954882,0.00004699734],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.005703093,0.00145369,0.01357253,0.001862416,0.0006483193,0.004982968,0.001107811,0.01782333,0.9008705,0.005803491,0.02123307,0.02493881],"study_design_scores_gemma":[0.001299553,0.001772299,0.1446083,0.0002107826,0.0006561437,0.006038235,0.001051571,0.1593584,0.6278095,0.001903744,0.05483585,0.0004556028],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9839332,0.007332073,0.001155635,0.0007808044,0.0001572344,0.00002438938,0.002553763,0.0002407389,0.00382216],"genre_scores_gemma":[0.9810851,0.003613539,0.002113541,0.0001487568,0.00004202605,0.00002023699,0.01008713,0.00006023147,0.002829514],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007818651,"threshold_uncertainty_score":0.01554626,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02702151539396848,"score_gpt":0.3197415574751397,"score_spread":0.2927200420811712,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}