{"id":"W2048352123","doi":"10.1007/s00439-011-1055-0","title":"Meta-analysis of new genome-wide association studies of colorectal cancer risk","year":2011,"lang":"en","type":"review","venue":"Human Genetics","topic":"Genetic Associations and Epidemiology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":208,"is_retracted":false,"has_abstract":false,"ca_institutions":"Memorial University of Newfoundland; Ontario Institute for Cancer Research; University of Toronto; University Health Network; Toronto General Hospital; Ottawa Hospital","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; National Institute of General Medical Sciences; National Heart, Lung, and Blood Institute; Medical Research Council; Canadian Institutes of Health Research; University at Buffalo; NIH Clinical Center; Groupement des Entreprises Françaises dans la lutte contre le Cancer; Canadian Cancer Society Research Institute; Deutsche Forschungsgemeinschaft; University of Pittsburgh; Conseil Régional des Pays de la Loire; Wellcome Trust; Institute of Genetics; University of Cincinnati; Association Anne de Bretagne Genetique; National Institute on Aging; Health Science Center, University of Tennessee; Division of Cancer Prevention, National Cancer Institute; University of Minnesota; National Cancer Institute; Wake Forest University; George Washington University; Northwestern University; University of Miami; University of North Carolina at Chapel Hill; Brigham and Women's Hospital; Kaiser Permanente; Emory University; Brown University; Ohio State University; University of Nevada, Reno; National Institutes of Health; U.S. Department of Health and Human Services; Women's Health Initiative; National Human Genome Research Institute; Wayne State University","keywords":"Genome-wide association study; Colorectal cancer; Single-nucleotide polymorphism; Biology; Odds ratio; Meta-analysis; Genetics; Genetic association; SNP; Oncology; Cancer; Bioinformatics; Internal medicine; Medicine; Genotype; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.008987484,0.002035701,0.006597246,0.002789319,0.0002084591,0.001299101,0.001999244,0.001230678,0.001415828],"category_scores_gemma":[0.01251743,0.0008237848,0.00579434,0.004626513,0.0003716832,0.0007602681,0.0009273117,0.001442426,0.0003154697],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007225991,"about_ca_system_score_gemma":0.00171132,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002362386,"about_ca_topic_score_gemma":0.006291195,"domain_scores_codex":[0.9968386,0.001433786,0.0004605061,0.000657727,0.0005125535,0.00009692291],"domain_scores_gemma":[0.9889168,0.008911091,0.0008862072,0.0005061841,0.0006501053,0.0001296287],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"meta_analysis","study_design_scores_codex":[0.002429905,0.00008986722,0.02763258,0.04892935,0.1609718,0.0008220983,0.00008295562,0.002344356,0.002301043,0.001191883,0.01393475,0.7392694],"study_design_scores_gemma":[0.001811614,0.001305209,0.1613049,0.02262239,0.5821226,0.009403613,0.0002335484,0.003759165,0.005258344,0.02002861,0.1917266,0.0004233725],"study_design_candidate":"meta_analysis","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.001273297,0.9963644,0.001536368,0.0003582542,0.0001247227,0.00000827167,0.0001765201,0.00002222261,0.000135961],"genre_scores_gemma":[0.0218035,0.9715834,0.004531694,0.0006357271,0.0005729333,0.00003663499,0.0006030966,0.00002200416,0.0002110987],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.008987484,"threshold_uncertainty_score":0.04753095,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2020570715827675,"score_gpt":0.3966965086713132,"score_spread":0.1946394370885457,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}