{"id":"W2048362135","doi":"10.1016/j.clinthera.2015.03.019","title":"Tolerability of Biphasic-Release Hydrocodone Bitartrate/Acetaminophen Tablets (MNK-155): A Phase III, Multicenter, Open-Label Study in Patients With Osteoarthritis or Chronic Low Back Pain","year":2015,"lang":"en","type":"article","venue":"Clinical Therapeutics","topic":"Pain Mechanisms and Treatments","field":"Medicine","cited_by":7,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"Mallinckrodt Pharmaceuticals","keywords":"Tolerability; Medicine; Acetaminophen; Hydrocodone; Discontinuation; Anesthesia; Adverse effect; Analgesic; Dosing; Clinical endpoint; Osteoarthritis; Internal medicine; Opioid; Oxycodone; Clinical trial","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.002614752,0.0004212525,0.001375909,0.00009437204,0.00006240709,0.0000445303,0.0003672078,0.000222826,0.0001548031],"category_scores_gemma":[0.0003070126,0.0002910489,0.00009614749,0.000439774,0.0002450437,0.000204889,0.0001739201,0.0004543106,0.00004278489],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002501134,"about_ca_system_score_gemma":0.0006110687,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00009415278,"about_ca_topic_score_gemma":0.0004017976,"domain_scores_codex":[0.9955954,0.001013581,0.001512421,0.000755247,0.0005771394,0.0005462168],"domain_scores_gemma":[0.9971417,0.0005723166,0.0004166318,0.0009892485,0.0003703762,0.0005097091],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.03572962,0.1230474,0.6946505,0.0001673809,0.0008581416,0.0003402536,0.0007004017,0.00001748011,0.0001636648,0.000005611795,0.00008216586,0.1442373],"study_design_scores_gemma":[0.7587634,0.1557738,0.07131439,0.001199287,0.0008557882,0.000007601919,0.0009091311,0.008536999,0.0006723427,0.0001354586,0.001044453,0.0007874318],"study_design_candidate":"randomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9932529,0.0003865492,0.0003253079,0.0001480127,0.0002009538,0.005492646,0.00007190785,0.00003480354,0.00008687395],"genre_scores_gemma":[0.9963037,0.00006702728,0.001980836,0.0009219937,0.00007520251,0.0001461287,0.0001074322,0.00006373935,0.0003339589],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.7230337,"threshold_uncertainty_score":0.9999542,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1435985044593683,"score_gpt":0.4098877593192153,"score_spread":0.2662892548598469,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}