{"id":"W2048362135","doi":"10.1016/j.clinthera.2015.03.019","title":"Tolerability of Biphasic-Release Hydrocodone Bitartrate/Acetaminophen Tablets (MNK-155): A Phase III, Multicenter, Open-Label Study in Patients With Osteoarthritis or Chronic Low Back Pain","year":2015,"lang":"en","type":"article","venue":"Clinical Therapeutics","topic":"Pain Mechanisms and Treatments","field":"Medicine","cited_by":7,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"Mallinckrodt Pharmaceuticals","keywords":"Tolerability; Medicine; Acetaminophen; Hydrocodone; Discontinuation; Anesthesia; Adverse effect; Analgesic; Dosing; Clinical endpoint; Osteoarthritis; Internal medicine; Opioid; Oxycodone; Clinical trial","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001184169,0.001410733,0.002148605,0.0004354006,0.0003679933,0.0008594209,0.0009513684,0.00101246,0.003522787],"category_scores_gemma":[0.000872255,0.0006250261,0.001521704,0.0004017046,0.001192269,0.001111978,0.0002993871,0.002804385,0.0007979996],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006255234,"about_ca_system_score_gemma":0.001267302,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001719745,"about_ca_topic_score_gemma":0.003733524,"domain_scores_codex":[0.9995466,0.000180239,0.00003236797,0.00008375099,0.00005370947,0.0001032959],"domain_scores_gemma":[0.9991928,0.0001529942,0.0001714719,0.00006275728,0.00005101722,0.0003690008],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.8340604,0.05906164,0.005477598,0.0008898967,0.001107924,0.0001541309,0.0003106754,0.001104872,0.03932966,0.0001225411,0.001346309,0.05703442],"study_design_scores_gemma":[0.5111283,0.4570556,0.02603796,0.00003867419,0.0005780014,0.0001730069,0.0001627666,0.001322158,0.002572489,0.00007253859,0.0008013864,0.00005708685],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9970207,0.001004244,0.0002850509,0.0001031163,0.00005873368,0.0005800541,0.000408317,0.00004900891,0.0004907542],"genre_scores_gemma":[0.9951715,0.001061103,0.0007694262,0.0003398232,0.0001347629,0.0005323571,0.0009463255,0.00002247064,0.001022198],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003522787,"threshold_uncertainty_score":0.01178491,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1435985044593683,"score_gpt":0.4098877593192153,"score_spread":0.2662892548598469,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}