{"id":"W2048362555","doi":"10.2174/13816128113199990369","title":"Needle-free Gene Delivery Through the Skin: An Overview of Recent Strategies","year":2013,"lang":"en","type":"review","venue":"Current Pharmaceutical Design","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Waterloo","funders":"Canadian Institutes of Health Research","keywords":"Niosome; Stratum corneum; Transdermal; Gene delivery; Electroporation; Genetic enhancement; Vesicle; Nanotechnology; Medicine; Chemistry; Pharmacology; Materials science; Pathology; Gene; Biochemistry; Membrane","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0003669013,0.0006357602,0.0009999144,0.00005623998,0.00009794009,0.0001094765,0.001605617,0.0003763994,0.0003730186],"category_scores_gemma":[0.00006601567,0.0004109087,0.0005757096,0.0002332208,0.0002945303,0.00002976943,0.0004790805,0.0005292621,0.0001207854],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003546734,"about_ca_system_score_gemma":0.0005769475,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001113862,"about_ca_topic_score_gemma":0.000001523145,"domain_scores_codex":[0.9967811,0.0008284385,0.0008437118,0.0007045877,0.000332193,0.000510023],"domain_scores_gemma":[0.9978202,0.00009995995,0.0003609198,0.001264986,0.0002732921,0.0001806656],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00003861377,0.0002538907,2.031155e-7,0.003321056,0.0003034607,0.00000261382,0.00003624434,0.0000133094,0.001238838,0.0003256511,0.01890813,0.975558],"study_design_scores_gemma":[0.0002879623,0.0003775736,8.263189e-7,0.001201393,0.0007776775,0.00002922925,0.0000495499,0.00003997904,0.00415487,0.0003353928,0.9922672,0.0004783678],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00007266902,0.9942659,0.003030899,0.00004041913,0.0008787835,0.001250578,0.0001267488,0.00001801257,0.0003160123],"genre_scores_gemma":[0.0000688306,0.9977666,0.0004977243,0.0001774879,0.0006989947,0.0002324383,0.0004307256,0.00006361322,0.00006356693],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9750796,"threshold_uncertainty_score":0.9998343,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.4318738866774468,"score_gpt":0.4731333906757996,"score_spread":0.04125950399835282,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}