{"id":"W2048367291","doi":"10.1208/s12249-014-0111-1","title":"Investigation of Dry Powder Inhaler (DPI) Resistance and Aerosol Dispersion Timing on Emitted Aerosol Aerodynamic Particle Sizing by Multistage Cascade Impactor when Sampled Volume Is Reduced from Compendial Value of 4 L","year":2014,"lang":"en","type":"article","venue":"AAPS PharmSciTech","topic":"Inhalation and Respiratory Drug Delivery","field":"Medicine","cited_by":14,"is_retracted":false,"has_abstract":false,"ca_institutions":"Intertek (Canada)","funders":"Teva Pharmaceutical Industries","keywords":"Aerosol; Dry-powder inhaler; Cascade impactor; Inhaler; Particle size; Bolus (digestion); Volumetric flow rate; Aerodynamic diameter; Materials science; Particle-size distribution; Chromatography; Chemistry; Medicine; Mechanics; Surgery; Asthma","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003252829,0.0002462206,0.0004758566,0.0001108182,0.0001300489,0.00002408452,0.0001152555,0.000182905,0.000225162],"category_scores_gemma":[0.0002138926,0.000222605,0.00009965594,0.0002072434,0.0002338218,0.0001975397,0.0000555185,0.0002726747,0.0000138277],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009959589,"about_ca_system_score_gemma":0.00005570243,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003760105,"about_ca_topic_score_gemma":0.00003280962,"domain_scores_codex":[0.998012,0.0001936072,0.0006002866,0.0004409844,0.0004659616,0.0002871685],"domain_scores_gemma":[0.9986538,0.0002330757,0.0003651881,0.0003792016,0.0001465827,0.000222166],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004121445,0.00007436532,0.02633555,0.0001165191,0.00005920009,0.000003602243,0.002137265,0.0000127771,0.9690268,0.00001476759,0.001094052,0.0007129489],"study_design_scores_gemma":[0.003979778,0.0002047282,0.02413118,0.0004569173,0.0001299955,0.00000192643,0.0002609917,0.01373345,0.956652,0.00002359646,0.0001676604,0.0002577816],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9979662,0.0002573299,0.0003401777,0.0004958115,0.0001418133,0.0004835333,0.0001753839,0.00005944999,0.0000802576],"genre_scores_gemma":[0.9972398,0.00002530468,0.001115305,0.0009063774,0.00009949114,0.00001010645,0.0001655677,0.00004203378,0.0003960342],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01372067,"threshold_uncertainty_score":0.9077567,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02165807271331291,"score_gpt":0.265387999905287,"score_spread":0.2437299271919741,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}