{"id":"W2048368680","doi":"10.1021/bi0500933","title":"Transmembrane Domain V of the Endothelin-A Receptor Is a Binding Domain of ET<sub>A</sub>-Selective TTA-386-Derived Photoprobes","year":2005,"lang":"en","type":"article","venue":"Biochemistry","topic":"Nitric Oxide and Endothelin Effects","field":"Medicine","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institut National de la Recherche Scientifique; Université du Québec à Montréal","funders":"","keywords":"Chemistry; Chinese hamster ovary cell; Receptor; Stereochemistry; Transmembrane domain; Cleavage (geology); Ligand (biochemistry); Amino acid; Binding site; Biochemistry; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008816594,0.0002019443,0.0001626132,0.00008069039,0.00009631545,0.0001275249,0.0001704273,0.0002324088,0.001135336],"category_scores_gemma":[0.0001242457,0.0001029014,0.0002177374,0.00008714709,0.0001244811,0.0001381193,0.0001295693,0.0002959631,0.0005581615],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003037894,"about_ca_system_score_gemma":0.00009388152,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003747226,"about_ca_topic_score_gemma":0.0002474921,"domain_scores_codex":[0.9999224,0.00001483836,0.000004204513,0.00002582456,0.00001881245,0.00001389833],"domain_scores_gemma":[0.9999501,0.00001139678,0.00001394503,0.000005393654,0.000005889105,0.0000134187],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003078199,0.000002719556,0.00003524743,0.000006843213,8.633813e-7,0.00001959747,0.000004302222,0.00001423413,0.9995583,0.00003940303,0.000007003691,0.0002808063],"study_design_scores_gemma":[0.00001938331,0.0001954871,0.005018479,0.000005741501,0.000007608995,0.0007239138,0.00001751524,0.0008130175,0.9879531,0.00007198328,0.005168859,0.000004836932],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9916838,0.0008954105,0.006094889,0.00006753015,0.00001878194,0.00002619503,0.000203757,0.00003520281,0.0009743548],"genre_scores_gemma":[0.9882978,0.0006204854,0.007113555,0.0001001321,0.00001039227,0.00003374805,0.0007556721,0.00001993683,0.003048498],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001135336,"threshold_uncertainty_score":0.003798127,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007602043562961159,"score_gpt":0.236567794445682,"score_spread":0.2289657508827208,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}