{"id":"W2048372556","doi":"10.1016/j.vaccine.2007.05.029","title":"TLR2 activation by proteosomes promotes uptake of particulate vaccines at mucosal surfaces","year":2007,"lang":"en","type":"article","venue":"Vaccine","topic":"Immunotherapy and Immune Responses","field":"Immunology and Microbiology","cited_by":44,"is_retracted":false,"has_abstract":false,"ca_institutions":"GlaxoSmithKline (Canada)","funders":"Eunice Kennedy Shriver National Institute of Child Health and Human Development; National Institute of Diabetes and Digestive and Kidney Diseases","keywords":"TLR2; In vivo; In vitro; Chemokine; Adjuvant; Chemistry; Cell biology; Matrix metalloproteinase; Immunology; Biology; Microbiology; Inflammation; Immune system; Innate immune system; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002726925,0.0005122494,0.0004561156,0.0002182225,0.0002158838,0.0007647977,0.0002004986,0.0007352869,0.00283222],"category_scores_gemma":[0.0002061007,0.0002893023,0.0005180123,0.00009191436,0.0002063711,0.000570695,0.000582004,0.001002264,0.001089124],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006608971,"about_ca_system_score_gemma":0.0003222847,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007027183,"about_ca_topic_score_gemma":0.0009331195,"domain_scores_codex":[0.9996607,0.00006989572,0.00001307931,0.0000496736,0.00005752909,0.0001490334],"domain_scores_gemma":[0.9998931,0.00002811717,0.00001865328,0.00001669491,0.00002008756,0.00002342276],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004284516,0.00006371773,0.0001427307,0.00005439167,0.000007749471,0.00006573201,0.00001921306,0.00007047712,0.9976503,0.0001395928,0.0001319401,0.001225659],"study_design_scores_gemma":[0.00004877713,0.000485307,0.003338626,0.00001536166,0.00001580775,0.0002489799,0.00007495765,0.00154662,0.992102,0.0001021954,0.00201507,0.000006438247],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9915131,0.002055475,0.003353429,0.0002031122,0.00008791575,0.00005207286,0.0001738679,0.00007530598,0.002485758],"genre_scores_gemma":[0.9945353,0.0004427683,0.001023143,0.0001000815,0.00002410216,0.00003220393,0.0002837726,0.00002788731,0.003530779],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00283222,"threshold_uncertainty_score":0.009474754,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009757796501999653,"score_gpt":0.2422152832842698,"score_spread":0.2324574867822701,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}