{"id":"W2048385227","doi":"10.1038/ni1080","title":"Acute myeloid leukemia originates from a hierarchy of leukemic stem cell classes that differ in self-renewal capacity","year":2004,"lang":"en","type":"article","venue":"Nature Immunology","topic":"Hematopoietic Stem Cell Transplantation","field":"Medicine","cited_by":974,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto; University Health Network","funders":"","keywords":"Stem cell; Leukemia; Haematopoiesis; Biology; Myeloid leukemia; Transplantation; Cancer stem cell; Cancer research; Immunology; Myeloid; Cell biology; Medicine; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002427954,0.0002297754,0.0005090481,0.0009797147,0.0003365921,0.0008603323,0.0003362769,0.0002722405,0.001292331],"category_scores_gemma":[0.00035282,0.0002110494,0.0002299619,0.0004271725,0.0003377341,0.0004288318,0.0007777861,0.001063644,0.0006878082],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003124817,"about_ca_system_score_gemma":0.0002781174,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002780821,"about_ca_topic_score_gemma":0.0003593861,"domain_scores_codex":[0.9996856,0.00003570428,0.0000334396,0.00004663632,0.0001096259,0.00008890488],"domain_scores_gemma":[0.9996904,0.00006718147,0.00007342838,0.00002926579,0.00005572578,0.00008402731],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002821687,0.00009099353,0.008782538,0.00004056104,0.00001799511,0.00009188929,0.0001281069,0.00007322567,0.9792926,0.002729194,0.0001861538,0.008284531],"study_design_scores_gemma":[0.0003915136,0.002628579,0.3885423,0.0001124973,0.0002551883,0.006904977,0.0008727685,0.003370348,0.5605573,0.008516788,0.02777746,0.0000701988],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9925274,0.001412615,0.002439523,0.0001402314,0.00001555244,0.00006594414,0.0003033888,0.00008297708,0.003012462],"genre_scores_gemma":[0.994473,0.0008110322,0.001980102,0.000187781,0.00004290125,0.00005776981,0.0008256512,0.00002976589,0.001591937],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001292331,"threshold_uncertainty_score":0.004323244,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009646016432307126,"score_gpt":0.2412596593377482,"score_spread":0.2316136429054411,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}