{"id":"W2048387831","doi":"10.1371/journal.pone.0077020","title":"Solution NMR Structure and Histone Binding of the PHD Domain of Human MLL5","year":2013,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Cancer-related gene regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":32,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ontario Institute for Cancer Research; BC Cancer Agency; University of Toronto; University Health Network; Structural Genomics Consortium","funders":"National Institute of General Medical Sciences; Natural Sciences and Engineering Research Council of Canada; Ontario Genomics; National Institutes of Health; Ministero dello Sviluppo Economico; Ontario Ministry of Economic Development and Innovation; Ontario Genomics Institute; Canadian Institutes of Health Research; Genome Canada; Wellcome Trust; GlaxoSmithKline; Pfizer; Eli Lilly and Company","keywords":"Histone H3; Histone; PHD finger; Chromatin; Biology; Protein domain; H3K4me3; Histone methyltransferase; Biochemistry; Computational biology; Cell biology; DNA; Zinc finger; Gene expression","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000175852,0.0003370252,0.0002556966,0.0001769828,0.0003906889,0.0003009401,0.0007828936,0.0005531879,0.002132475],"category_scores_gemma":[0.0004436302,0.0002232584,0.0002368856,0.0002696529,0.0003227004,0.0003830927,0.0003163856,0.0008874903,0.0002906504],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008135968,"about_ca_system_score_gemma":0.0002856767,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004253581,"about_ca_topic_score_gemma":0.003480058,"domain_scores_codex":[0.9999214,0.0000136313,0.000003069149,0.00001778836,0.00002374699,0.00002032133],"domain_scores_gemma":[0.9998368,0.00004591673,0.00003600301,0.00001063591,0.00002757847,0.00004305636],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001623798,0.0002100959,0.00319608,0.0005032856,0.0001392665,0.0006357288,0.000478913,0.01375814,0.9658329,0.002780571,0.003212482,0.007628705],"study_design_scores_gemma":[0.0006807963,0.001958743,0.04610975,0.0001633737,0.0003077939,0.001098985,0.00152444,0.1985969,0.7160353,0.003047596,0.03020959,0.0002666711],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9892091,0.001776913,0.004256599,0.0005989014,0.00004420283,0.00001751029,0.00067732,0.00009792333,0.00332159],"genre_scores_gemma":[0.9922955,0.0009319161,0.002721273,0.0001756171,0.00002732601,0.00001564691,0.002755177,0.00002585956,0.001051703],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004253581,"threshold_uncertainty_score":0.008457601,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01543902739562744,"score_gpt":0.2219492810402016,"score_spread":0.2065102536445741,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}