{"id":"W2048387831","doi":"10.1371/journal.pone.0077020","title":"Solution NMR Structure and Histone Binding of the PHD Domain of Human MLL5","year":2013,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Cancer-related gene regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":32,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ontario Institute for Cancer Research; BC Cancer Agency; University of Toronto; University Health Network; Structural Genomics Consortium","funders":"National Institute of General Medical Sciences; Natural Sciences and Engineering Research Council of Canada; Ontario Genomics; National Institutes of Health; Ministero dello Sviluppo Economico; Ontario Ministry of Economic Development and Innovation; Ontario Genomics Institute; Canadian Institutes of Health Research; Genome Canada; Wellcome Trust; GlaxoSmithKline; Pfizer; Eli Lilly and Company","keywords":"Histone H3; Histone; PHD finger; Chromatin; Biology; Protein domain; H3K4me3; Histone methyltransferase; Biochemistry; Computational biology; Cell biology; DNA; Zinc finger; Gene expression","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00003747067,0.00005461077,0.0000880665,0.00002084407,0.00004243699,0.000003035373,0.00006048896,0.00009398219,0.00003243835],"category_scores_gemma":[0.0000136965,0.00004476612,0.00002540382,0.00005025287,0.00008568276,0.000002618881,0.00005156812,0.00004127884,5.94203e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000167453,"about_ca_system_score_gemma":0.00001502144,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005616422,"about_ca_topic_score_gemma":0.00004052188,"domain_scores_codex":[0.9995732,0.00002320147,0.0001215913,0.0001074473,0.0001023455,0.00007225798],"domain_scores_gemma":[0.9996246,0.000002610722,0.0001129843,0.0001855779,0.00005742875,0.00001685953],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000006678389,0.00004182685,0.00217811,0.00003936236,0.00005692061,1.312922e-8,0.00005295553,0.00001050576,0.997152,0.00004123712,0.0001435253,0.0002768401],"study_design_scores_gemma":[0.0002415174,0.00007660875,0.0218837,0.00004273984,0.00003564039,8.25433e-7,0.00001448994,0.0000553959,0.9772379,0.0003256796,0.000035141,0.00005033055],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9990226,0.0004882334,0.00002915119,0.0001335617,0.00001982502,0.0001768482,0.00001281562,0.000002701029,0.0001142881],"genre_scores_gemma":[0.9991458,0.00002559499,0.0004363619,0.000008797507,0.00005962444,0.000004527522,0.00003027821,0.000007859367,0.000281166],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01991409,"threshold_uncertainty_score":0.182551,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01543902739562744,"score_gpt":0.2219492810402016,"score_spread":0.2065102536445741,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}