{"id":"W2048393533","doi":"10.1002/jmv.21329","title":"PL‐100, a novel HIV‐1 protease inhibitor displaying a high genetic barrier to resistance: An in vitro selection study","year":2008,"lang":"en","type":"article","venue":"Journal of Medical Virology","topic":"HIV/AIDS drug development and treatment","field":"Medicine","cited_by":21,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Jewish General Hospital; PerkinElmer Biosignal","funders":"","keywords":"Nelfinavir; Protease; Virology; Biology; Mutation; Indinavir; Saquinavir; Mutagenesis; Protease inhibitor (pharmacology); Amprenavir; Virus; Mutant; Drug resistance; Viral replication; Molecular biology; HIV-1 protease; Genetics; Enzyme; Gene; Viral disease; Viral load; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007974404,0.0001811148,0.0005751252,0.0004373468,0.00009525009,0.000007312559,0.0001497496,0.000193751,0.0002093077],"category_scores_gemma":[0.0006195747,0.0001327531,0.0000742679,0.0003401845,0.0000691673,0.00008067568,0.00004639532,0.0006326447,0.00002176822],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00029748,"about_ca_system_score_gemma":0.0006946291,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002868444,"about_ca_topic_score_gemma":0.00013579,"domain_scores_codex":[0.9973522,0.0001882125,0.0007752517,0.0002589453,0.001082545,0.0003428491],"domain_scores_gemma":[0.9987249,0.00008618216,0.000184644,0.0001376125,0.0001140752,0.0007525693],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.02778512,0.0197999,0.713079,0.0001377881,0.0009124954,0.03338053,0.01645484,0.0000669874,0.1679135,0.00005529144,0.01244223,0.007972408],"study_design_scores_gemma":[0.03918504,0.006479433,0.9201752,0.0004152842,0.0004077508,0.006326854,0.001148261,0.0004745272,0.008306754,0.00006890721,0.0165425,0.0004695203],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9838332,0.0001145187,0.0009252057,0.01425439,0.0002056115,0.0006225937,0.00000252476,0.00001318894,0.00002875065],"genre_scores_gemma":[0.9908552,0.00003059824,0.006577392,0.0009144534,0.0005795198,0.00005531238,0.000003813507,0.0000216574,0.0009621238],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2070962,"threshold_uncertainty_score":0.5413513,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01723492474251681,"score_gpt":0.2910066199309507,"score_spread":0.2737716951884339,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}