{"id":"W2048393533","doi":"10.1002/jmv.21329","title":"PL‐100, a novel HIV‐1 protease inhibitor displaying a high genetic barrier to resistance: An in vitro selection study","year":2008,"lang":"en","type":"article","venue":"Journal of Medical Virology","topic":"HIV/AIDS drug development and treatment","field":"Medicine","cited_by":21,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Jewish General Hospital; PerkinElmer Biosignal","funders":"","keywords":"Nelfinavir; Protease; Virology; Biology; Mutation; Indinavir; Saquinavir; Mutagenesis; Protease inhibitor (pharmacology); Amprenavir; Virus; Mutant; Drug resistance; Viral replication; Molecular biology; HIV-1 protease; Genetics; Enzyme; Gene; Viral disease; Viral load; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000205775,0.0004022653,0.0003362064,0.0001590432,0.0001536932,0.0002897804,0.000294092,0.0002024624,0.0006445936],"category_scores_gemma":[0.0001956691,0.0001410972,0.0002065378,0.0001939657,0.0001399572,0.0001703849,0.0001445511,0.0004800794,0.0003138435],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002271783,"about_ca_system_score_gemma":0.000126822,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000728972,"about_ca_topic_score_gemma":0.0007589596,"domain_scores_codex":[0.9998114,0.00006401807,0.00001289755,0.00003209858,0.00005589903,0.00002375405],"domain_scores_gemma":[0.9998596,0.00006357227,0.00002174482,0.00001405222,0.00001742782,0.00002369612],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008036852,0.0001180556,0.0001861912,0.00002360415,0.000004790283,0.00008103486,0.00001309669,0.0003120484,0.9974687,0.00004101582,0.00003759859,0.00163357],"study_design_scores_gemma":[0.00002534426,0.001628699,0.001811136,0.000004963067,0.00002612711,0.0004623095,0.00001937662,0.002295781,0.9918651,0.00002006371,0.001833508,0.000007576959],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9921653,0.001644853,0.003951622,0.00008510688,0.00001290339,0.00004678609,0.0002306981,0.00003748109,0.001825192],"genre_scores_gemma":[0.9905325,0.001780137,0.004152227,0.00005957037,0.00001230184,0.00003652423,0.00102848,0.00003211178,0.00236618],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.000728972,"threshold_uncertainty_score":0.002156377,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01723492474251681,"score_gpt":0.2910066199309507,"score_spread":0.2737716951884339,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}