{"id":"W2048395913","doi":"10.1038/icb.2010.119","title":"Molecular and genetic parameters defining T‐cell clonal selection","year":2010,"lang":"en","type":"review","venue":"Immunology and Cell Biology","topic":"T-cell and B-cell Immunology","field":"Immunology and Microbiology","cited_by":31,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta; Université de Montréal; Hôpital Maisonneuve-Rosemont","funders":"Canadian Institutes of Health Research","keywords":"Biology; Clonal deletion; Clonal selection; Selection (genetic algorithm); Repertoire; Negative selection; Somatic evolution in cancer; Positive selection; Genetics; Genome; Computational biology; Evolutionary biology; T cell; Immunology; Gene; T-cell receptor; Immune system","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007388024,0.001038672,0.001433191,0.002405924,0.0002184078,0.001260812,0.001182805,0.001175195,0.001024161],"category_scores_gemma":[0.0007484201,0.0003834625,0.0002826648,0.001676236,0.001256581,0.001410242,0.0007110738,0.002101394,0.001843928],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001121255,"about_ca_system_score_gemma":0.0009194512,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007899156,"about_ca_topic_score_gemma":0.0006558944,"domain_scores_codex":[0.9996424,0.00005923283,0.0000470946,0.00007591138,0.0001392397,0.00003623483],"domain_scores_gemma":[0.9996458,0.000134771,0.00006406951,0.00001512723,0.0001075952,0.00003256383],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001456197,0.00007138073,0.0007502044,0.01122168,0.00006941509,0.000859202,0.0001207582,0.001270837,0.0475147,0.02809475,0.01752265,0.8923589],"study_design_scores_gemma":[0.00002358667,0.00008922142,0.003213943,0.001711684,0.00008437395,0.00523127,0.0001101921,0.0003842479,0.01419342,0.01294925,0.9619412,0.00006762752],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0006238895,0.9950787,0.001289684,0.0002754631,0.0002884709,0.000008386975,0.00002901461,0.00001741375,0.002388878],"genre_scores_gemma":[0.003139537,0.9944296,0.0009079238,0.0001861662,0.0003460007,0.00001900216,0.00005063045,0.000003993922,0.0009172718],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002405924,"threshold_uncertainty_score":0.008135319,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01144259740501608,"score_gpt":0.2372824656748682,"score_spread":0.2258398682698521,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}