{"id":"W2048427935","doi":"10.1002/ddr.10127","title":"Endothelial cell dysfunction in type I and II diabetes: The cellular basis for dysfunction","year":2003,"lang":"en","type":"article","venue":"Drug Development Research","topic":"Nitric Oxide and Endothelin Effects","field":"Medicine","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"Canadian Diabetes Association; Pfizer","keywords":"Endothelial dysfunction; Tetrahydrobiopterin; Enos; Oxidative stress; Nitric oxide; Endocrinology; Internal medicine; Polyol pathway; Chemistry; Endothelium; Bradykinin; Glycation; Nitric oxide synthase; Endothelial stem cell; Vasodilation; Superoxide; Diabetes mellitus; Pharmacology; Medicine; Biochemistry; Receptor; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002377955,0.0002535665,0.0002627459,0.0002891507,0.000122201,0.0004279148,0.0001493342,0.0003776878,0.002036219],"category_scores_gemma":[0.000167671,0.0000638943,0.00009779847,0.0002121872,0.0003077219,0.0002927674,0.0001846724,0.0007243489,0.0003395468],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002483416,"about_ca_system_score_gemma":0.0001222019,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001885638,"about_ca_topic_score_gemma":0.0002486384,"domain_scores_codex":[0.9999427,0.00001377486,0.000005242887,0.000007610683,0.00001705715,0.000013611],"domain_scores_gemma":[0.9999086,0.00001539185,0.00002009778,0.000007012068,0.00001627673,0.00003259399],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.004173276,0.0009472809,0.03929153,0.002285534,0.000179837,0.004818189,0.0003134927,0.0007312509,0.6371257,0.01275868,0.01068467,0.2866904],"study_design_scores_gemma":[0.0006088775,0.005810707,0.5731395,0.001224855,0.0007452103,0.02832063,0.001159127,0.004257489,0.2473376,0.02458067,0.1127344,0.00008095274],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7225286,0.2444922,0.004824601,0.0086101,0.001138217,0.0000380927,0.0006313461,0.0001061685,0.01763075],"genre_scores_gemma":[0.9256856,0.06630669,0.00111859,0.0007855108,0.0004964772,0.0000235748,0.0002172416,0.000004750203,0.00536175],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002036219,"threshold_uncertainty_score":0.006811798,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03692807516046203,"score_gpt":0.2966105482097622,"score_spread":0.2596824730493001,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}