{"id":"W2048427935","doi":"10.1002/ddr.10127","title":"Endothelial cell dysfunction in type I and II diabetes: The cellular basis for dysfunction","year":2003,"lang":"en","type":"article","venue":"Drug Development Research","topic":"Nitric Oxide and Endothelin Effects","field":"Medicine","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"Canadian Diabetes Association; Pfizer","keywords":"Endothelial dysfunction; Tetrahydrobiopterin; Enos; Oxidative stress; Nitric oxide; Endocrinology; Internal medicine; Polyol pathway; Chemistry; Endothelium; Bradykinin; Glycation; Nitric oxide synthase; Endothelial stem cell; Vasodilation; Superoxide; Diabetes mellitus; Pharmacology; Medicine; Biochemistry; Receptor; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00324288,0.0001341359,0.0001896419,0.000311162,0.0003815628,0.00003097622,0.00007516006,0.00007991444,0.0001170088],"category_scores_gemma":[0.000853049,0.00009241257,0.00003088532,0.0006930796,0.0000722209,0.00006209979,0.00005529668,0.0003513354,0.00007332006],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001997449,"about_ca_system_score_gemma":0.0004074,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002677394,"about_ca_topic_score_gemma":0.0000244914,"domain_scores_codex":[0.9982269,0.0002280429,0.0002333181,0.000315533,0.0004759166,0.0005203242],"domain_scores_gemma":[0.9988095,0.0005837605,0.00003026382,0.00021414,0.00025475,0.0001076445],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002637671,0.001836522,0.1847075,0.002332042,0.0002839736,0.00007453263,0.0145862,0.00004188711,0.6213177,0.001547413,0.05060811,0.1200264],"study_design_scores_gemma":[0.004299034,0.0005058449,0.009863353,0.0001562853,0.00003227603,0.00000492338,0.001545753,0.0002986289,0.5883324,0.0003814551,0.3943459,0.0002341522],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9924698,0.0007742319,0.0001517357,0.0007550907,0.0002880907,0.001166934,0.000001926787,0.00002602377,0.004366186],"genre_scores_gemma":[0.9852117,0.0001499775,0.001173353,0.00017678,0.0001203695,0.0002648335,0.00002065206,0.00002788528,0.0128545],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3437378,"threshold_uncertainty_score":0.3768475,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03692807516046203,"score_gpt":0.2966105482097622,"score_spread":0.2596824730493001,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}