{"id":"W2048442759","doi":"10.1371/journal.pgen.1001082","title":"Methylated H3K4, a Transcription-Associated Histone Modification, Is Involved in the DNA Damage Response Pathway","year":2010,"lang":"en","type":"article","venue":"PLoS Genetics","topic":"Genomics and Chromatin Dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":163,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Sherbrooke","funders":"Canadian Institutes of Health Research","keywords":"Biology; H3K4me3; Histone methylation; Histone methyltransferase; Histone code; Histone; Chromatin; Histone H2A; Cell biology; Epigenomics; Chromatin remodeling; DNA damage; DNA repair; Genetics; DNA methylation; Nucleosome; DNA; Promoter; Gene; Gene expression","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001073485,0.0004393973,0.0002787301,0.0003518573,0.0004174007,0.0003831778,0.0003266693,0.0003416268,0.003140535],"category_scores_gemma":[0.0001765764,0.0001622358,0.0003692832,0.0003765433,0.0002244048,0.0002395932,0.0004421203,0.0003566254,0.0009198245],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005544455,"about_ca_system_score_gemma":0.0003242778,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001617028,"about_ca_topic_score_gemma":0.001414416,"domain_scores_codex":[0.9998714,0.00001375666,0.000008993178,0.00003840954,0.00004244806,0.00002512898],"domain_scores_gemma":[0.9998989,0.000007394249,0.00003495897,0.0000105352,0.00001859884,0.00002963898],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004266898,0.00002302563,0.00425146,0.0001964852,0.00006635857,0.0001542902,0.00002436416,0.000226737,0.9858148,0.0002625041,0.0002328151,0.00832056],"study_design_scores_gemma":[0.0000274586,0.0001884329,0.08803833,0.00002773478,0.00009758799,0.0008921631,0.00009277704,0.001801516,0.8941653,0.000972385,0.01367047,0.00002581889],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9516526,0.022329,0.01442618,0.0004378018,0.0001929486,0.00006379083,0.004336442,0.0005324353,0.006028807],"genre_scores_gemma":[0.9882289,0.002260478,0.002228422,0.00005474568,0.00001649934,0.00001797129,0.001943966,0.00003236934,0.005216689],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003140535,"threshold_uncertainty_score":0.01050615,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01701000596764692,"score_gpt":0.2489991170271263,"score_spread":0.2319891110594793,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}