{"id":"W2048443894","doi":"10.1038/nsmb.2149","title":"miRNA-mediated deadenylation is orchestrated by GW182 through two conserved motifs that interact with CCR4–NOT","year":2011,"lang":"en","type":"article","venue":"Nature Structural & Molecular Biology","topic":"RNA Research and Splicing","field":"Biochemistry, Genetics and Molecular Biology","cited_by":328,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto; Ontario Institute for Cancer Research; McGill University Health Centre; McGill University","funders":"Canadian Institutes of Health Research; Howard Hughes Medical Institute","keywords":"Argonaute; Gene silencing; Biology; Psychological repression; Genetics; Cell biology; RasiRNA; RNA interference; RNA; Gene; Gene expression","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003742911,0.0005961032,0.0005851039,0.0002183457,0.0005900487,0.0008571866,0.0005829717,0.0006855325,0.004339093],"category_scores_gemma":[0.0003498918,0.0003371583,0.0007136705,0.0001245333,0.0004723479,0.000459916,0.000622326,0.00114452,0.002539298],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00060928,"about_ca_system_score_gemma":0.0004152493,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005187523,"about_ca_topic_score_gemma":0.001032197,"domain_scores_codex":[0.9995308,0.00006298528,0.00004183498,0.0001679127,0.00008810233,0.0001084469],"domain_scores_gemma":[0.9996597,0.00003485023,0.0001218241,0.00005287565,0.00002441195,0.0001063617],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000311432,0.00002860687,0.0003829795,0.00003471415,0.00001477253,0.0002721622,0.00001919681,0.0001142299,0.9958887,0.0008339629,0.0002034148,0.001895995],"study_design_scores_gemma":[0.00005152103,0.0001156251,0.003026023,0.000006197503,0.00001350742,0.000667734,0.00002710016,0.002095492,0.9875672,0.000203127,0.006207874,0.00001851087],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9715949,0.001755301,0.02032169,0.0003215858,0.0002343267,0.00006999422,0.000382078,0.0008351371,0.004485087],"genre_scores_gemma":[0.9884128,0.0001513979,0.00652324,0.0001204122,0.00001785141,0.00003486431,0.000462811,0.000125214,0.004151445],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004339093,"threshold_uncertainty_score":0.01451576,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01800041852617543,"score_gpt":0.3169517546856626,"score_spread":0.2989513361594872,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}