{"id":"W2048461731","doi":"10.1139/o09-003","title":"Investigation of residues Lys112, Glu136, His138, Gly247, Tyr248, and Asp249 in the active site of yeast cystathionine β-synthase","year":2009,"lang":"en","type":"article","venue":"Biochemistry and Cell Biology","topic":"Folate and B Vitamins Research","field":"Medicine","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"Carleton University","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Cystathionine beta synthase; Span (engineering); Mutant; Stereochemistry; Serine; Biology; Chemistry; Biochemistry; Gene; Enzyme; Cysteine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001453276,0.0005272286,0.0003477532,0.0001134657,0.0001816457,0.0002426295,0.0003873661,0.0003961869,0.0009550729],"category_scores_gemma":[0.0002276162,0.0001626925,0.0004891192,0.0001752727,0.0001998371,0.0002370614,0.0001748945,0.0004088228,0.0003157874],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004136945,"about_ca_system_score_gemma":0.000234155,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00173984,"about_ca_topic_score_gemma":0.001163463,"domain_scores_codex":[0.9999092,0.00001879339,0.000007586197,0.00001899928,0.0000310086,0.00001446017],"domain_scores_gemma":[0.9998803,0.00003077849,0.00004463552,0.000006163711,0.00001402712,0.00002405385],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002009553,0.0002837114,0.005244311,0.0003134122,0.00009177476,0.001989948,0.0001340351,0.005649363,0.9786486,0.0005478719,0.0002044694,0.004882896],"study_design_scores_gemma":[0.0003140666,0.001658673,0.02356132,0.00005280002,0.000245502,0.002914294,0.000475728,0.02581646,0.9396963,0.000281941,0.004933561,0.00004917974],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9978415,0.0003081836,0.001269475,0.00003483448,0.000009220812,0.00001420104,0.0001676294,0.0000169078,0.0003380305],"genre_scores_gemma":[0.9975327,0.0002421919,0.001353889,0.00001722247,0.000003135989,0.000008108162,0.0003752787,0.000006904433,0.0004605284],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00173984,"threshold_uncertainty_score":0.003459454,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01713945077163821,"score_gpt":0.2729739787252833,"score_spread":0.2558345279536451,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}