{"id":"W2048478593","doi":"10.1038/npp.2013.183","title":"Acute Effects of Sceletium tortuosum (Zembrin), a Dual 5-HT Reuptake and PDE4 Inhibitor, in the Human Amygdala and its Connection to the Hypothalamus","year":2013,"lang":"en","type":"article","venue":"Neuropsychopharmacology","topic":"Chemical synthesis and alkaloids","field":"Chemistry","cited_by":64,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"H. Lundbeck A/S; GlaxoSmithKline; Jazz Pharmaceuticals; Servier; Pfizer; AstraZeneca; Eli Lilly and Company","keywords":"Amygdala; Psychology; Anxiety; Anxiolytic; Anxiogenic; Neuroscience; Medicine; Psychiatry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001460324,0.0002082449,0.0002639538,0.00005022086,0.0001167055,0.00004073554,0.0002356027,0.0001220049,0.0002913423],"category_scores_gemma":[0.0001028929,0.0001371004,0.00005336599,0.000163249,0.0001191709,0.00006229294,0.0001260425,0.0003832307,0.00002249076],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001656108,"about_ca_system_score_gemma":0.00001044288,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004483868,"about_ca_topic_score_gemma":0.00001235398,"domain_scores_codex":[0.99867,0.0001381171,0.0003092347,0.0004047001,0.000164714,0.0003132382],"domain_scores_gemma":[0.9989088,0.0006019146,0.0001038832,0.0002326702,0.00004524291,0.0001074922],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005468578,0.0001247065,0.0007003053,0.00009301193,0.00003183611,0.00003290642,0.0002659977,7.644009e-7,0.9898182,0.00005527425,0.005684859,0.003137457],"study_design_scores_gemma":[0.002603182,0.0002458458,0.04508231,0.00005357124,0.0001241213,0.0001617753,0.0001044429,0.00007957999,0.9322912,0.0001167293,0.01886237,0.000274832],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9936804,0.000351443,3.451334e-7,0.003286862,0.0003425131,0.0004181199,0.000007673544,0.00002815575,0.001884459],"genre_scores_gemma":[0.9969985,0.0001890852,0.000006220319,0.001840316,0.0003880683,0.0001932523,0.000002351099,0.00002498484,0.0003572052],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05752696,"threshold_uncertainty_score":0.5590791,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009086976712572878,"score_gpt":0.2557472680996397,"score_spread":0.2466602913870668,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}