{"id":"W2048478593","doi":"10.1038/npp.2013.183","title":"Acute Effects of Sceletium tortuosum (Zembrin), a Dual 5-HT Reuptake and PDE4 Inhibitor, in the Human Amygdala and its Connection to the Hypothalamus","year":2013,"lang":"en","type":"article","venue":"Neuropsychopharmacology","topic":"Chemical synthesis and alkaloids","field":"Chemistry","cited_by":64,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"H. Lundbeck A/S; GlaxoSmithKline; Jazz Pharmaceuticals; Servier; Pfizer; AstraZeneca; Eli Lilly and Company","keywords":"Amygdala; Psychology; Anxiety; Anxiolytic; Anxiogenic; Neuroscience; Medicine; Psychiatry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009332383,0.0002528293,0.0002333162,0.0001060127,0.0001352109,0.0001271209,0.0001165868,0.0002432978,0.001679765],"category_scores_gemma":[0.0001782934,0.0001971816,0.00013427,0.00008453627,0.0003641513,0.0001977682,0.0001426256,0.0003611002,0.0001096409],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001156136,"about_ca_system_score_gemma":0.0001305223,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008692605,"about_ca_topic_score_gemma":0.002038086,"domain_scores_codex":[0.999957,0.00001268899,0.000003100356,0.00001141448,0.000005769938,0.00001016701],"domain_scores_gemma":[0.9999506,0.00001379328,0.0000130137,0.000005205145,0.000003370902,0.00001397195],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.02037515,0.0009681369,0.0008999471,0.0001310158,0.00003901923,0.00006251993,0.00009798513,0.00008046044,0.9713755,0.00004095167,0.00004712919,0.005882232],"study_design_scores_gemma":[0.003086708,0.1021677,0.1265333,0.00003376265,0.0003518937,0.0005043959,0.0003353766,0.001738112,0.7630128,0.0001628619,0.002044881,0.00002816405],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9991061,0.0004666759,0.0001359033,0.00003327069,0.000007016738,0.00002084731,0.00004786768,0.000007218921,0.0001751371],"genre_scores_gemma":[0.998262,0.000581572,0.0002850803,0.00004196349,0.00001601681,0.00004274632,0.00006274517,0.000002528264,0.0007053149],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001679765,"threshold_uncertainty_score":0.005619407,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009086976712572878,"score_gpt":0.2557472680996397,"score_spread":0.2466602913870668,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}