{"id":"W2048485377","doi":"10.1016/j.ymthe.2006.03.021","title":"Protective Regulatory T Cell Generation in Autoimmune Diabetes by DNA Covaccination with Islet Antigens and a Selective CTLA-4 Ligand","year":2006,"lang":"en","type":"article","venue":"Molecular Therapy","topic":"Diabetes and associated disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":24,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; St. Michael's Hospital","funders":"","keywords":"IL-2 receptor; Insulitis; FOXP3; DNA vaccination; Antigen; Biology; Adoptive cell transfer; Cytotoxic T cell; Immunology; CD28; CTLA-4; Islet; T cell; Antibody; Immune system; Autoimmune disease; In vitro; Endocrinology; Insulin; Immunization","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001323889,0.0001796218,0.0001496946,0.00005595663,0.00007584572,0.00004318912,0.00006390177,0.0001439025,0.000002259452],"category_scores_gemma":[0.000006880035,0.0001669559,0.00003698739,0.0001629984,0.00004168916,0.000009033961,0.00001673078,0.00008028333,8.910473e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002643714,"about_ca_system_score_gemma":0.0000399723,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007524598,"about_ca_topic_score_gemma":0.00004568982,"domain_scores_codex":[0.9990496,0.00009012698,0.0001434165,0.0003537383,0.0001170966,0.0002460058],"domain_scores_gemma":[0.9996471,0.000004175837,0.00009324738,0.000151136,0.00007961892,0.00002469362],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004015962,0.0001507075,0.006072801,0.00000531662,0.00004690216,0.000001578843,0.00006008856,0.0002140384,0.9914217,0.00001619224,0.0004920694,0.001478462],"study_design_scores_gemma":[0.00182313,0.0004582024,0.0119226,0.000007911635,0.000007837827,6.350269e-7,0.00002139468,0.0002953212,0.9836808,0.0001916978,0.001355318,0.0002351929],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9936255,0.004741357,0.0006735168,0.0001389756,0.00001581585,0.0004935066,0.0000129193,0.00001428519,0.0002841593],"genre_scores_gemma":[0.9989395,0.000141119,0.00009920902,0.0002365304,0.00003246563,0.00008583074,0.0003070423,0.00003368584,0.0001246218],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007740921,"threshold_uncertainty_score":0.6808264,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00215521972127607,"score_gpt":0.177163983763948,"score_spread":0.1750087640426719,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}