{"id":"W2048485377","doi":"10.1016/j.ymthe.2006.03.021","title":"Protective Regulatory T Cell Generation in Autoimmune Diabetes by DNA Covaccination with Islet Antigens and a Selective CTLA-4 Ligand","year":2006,"lang":"en","type":"article","venue":"Molecular Therapy","topic":"Diabetes and associated disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":24,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; St. Michael's Hospital","funders":"","keywords":"IL-2 receptor; Insulitis; FOXP3; DNA vaccination; Antigen; Biology; Adoptive cell transfer; Cytotoxic T cell; Immunology; CD28; CTLA-4; Islet; T cell; Antibody; Immune system; Autoimmune disease; In vitro; Endocrinology; Insulin; Immunization","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002447249,0.0005924643,0.0002879199,0.0002547117,0.0001244479,0.00024953,0.0002127599,0.0003684337,0.000847399],"category_scores_gemma":[0.0001989923,0.0001746824,0.0002498335,0.00008993223,0.0003163874,0.000204216,0.00019566,0.0009445097,0.0002461742],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001659028,"about_ca_system_score_gemma":0.0001940367,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001300182,"about_ca_topic_score_gemma":0.0001724556,"domain_scores_codex":[0.9998161,0.00003852656,0.00001660424,0.00003489159,0.00003417127,0.00005974286],"domain_scores_gemma":[0.9998597,0.00002635554,0.00003565948,0.00001866115,0.00001191052,0.00004776438],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003720017,0.0001456359,0.0003179232,0.00006814152,0.000007048948,0.0001021032,0.00002880935,0.000156622,0.9945169,0.0001385718,0.00003040234,0.004115823],"study_design_scores_gemma":[0.0003209841,0.004153317,0.004133144,0.00002291893,0.00007156312,0.0008889699,0.0000414475,0.001719048,0.986279,0.0002047046,0.002156517,0.000008478404],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9964464,0.001032907,0.001426431,0.00006159575,0.0000320675,0.00002695501,0.00003638609,0.0001103987,0.0008268896],"genre_scores_gemma":[0.9975611,0.0004138988,0.0009773595,0.00005419994,0.00002222228,0.0000362001,0.00008850796,0.00001559863,0.0008308465],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.000847399,"threshold_uncertainty_score":0.002834857,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00215521972127607,"score_gpt":0.177163983763948,"score_spread":0.1750087640426719,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}