{"id":"W2048492290","doi":"10.1126/science.1216283","title":"Elementary Ca <sup>2+</sup> Signals Through Endothelial TRPV4 Channels Regulate Vascular Function","year":2012,"lang":"en","type":"article","venue":"Science","topic":"Ion Channels and Receptors","field":"Neuroscience","cited_by":544,"is_retracted":false,"has_abstract":true,"ca_institutions":"Montreal Heart Institute","funders":"National Center for Research Resources; National Institute of General Medical Sciences; National Institute of Diabetes and Digestive and Kidney Diseases; National Heart, Lung, and Blood Institute","keywords":"TRPV4; Gating; Vasodilation; Chemistry; Potassium channel; Biophysics; Vascular smooth muscle; Transcellular; Transient receptor potential channel; Ion channel; SK channel; Cell biology; Endothelium; Endocrinology; Receptor; Biology; Biochemistry; Smooth muscle","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.001125576,0.000228447,0.000194102,0.0001602601,0.0008762913,0.0001368839,0.0006254905,0.00007181858,0.001149619],"category_scores_gemma":[0.000198569,0.0001794009,0.0001318916,0.001079396,0.0007404981,0.001948294,0.0002014187,0.0001802468,0.0007657543],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000100375,"about_ca_system_score_gemma":0.0001017785,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005597331,"about_ca_topic_score_gemma":5.820334e-7,"domain_scores_codex":[0.9967769,0.0001304156,0.0002893816,0.000667283,0.001082505,0.001053547],"domain_scores_gemma":[0.9991522,0.00007745263,0.000110596,0.0003317513,0.00006662841,0.000261352],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003540135,0.0001891433,0.00009246445,0.00001810236,0.000007203853,0.000004023321,0.004910241,0.008083722,0.9794345,0.00175539,0.002140084,0.003329668],"study_design_scores_gemma":[0.0004012729,0.0001549679,0.00009020704,0.00002368092,0.00001770716,0.00002136361,0.0005974579,0.007018076,0.9224291,0.00136015,0.06756136,0.0003246622],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9876364,0.0002350401,0.003291456,0.0005177181,0.0049823,0.00045819,0.00002907724,0.0001533786,0.002696405],"genre_scores_gemma":[0.9954338,0.00009918305,0.0002448305,0.001839263,0.001026183,0.00002863505,0.000002747338,0.00002138559,0.001303978],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.06542128,"threshold_uncertainty_score":0.9997635,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03471136893369143,"score_gpt":0.271526070476263,"score_spread":0.2368147015425716,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}