{"id":"W2048492290","doi":"10.1126/science.1216283","title":"Elementary Ca <sup>2+</sup> Signals Through Endothelial TRPV4 Channels Regulate Vascular Function","year":2012,"lang":"en","type":"article","venue":"Science","topic":"Ion Channels and Receptors","field":"Neuroscience","cited_by":544,"is_retracted":false,"has_abstract":true,"ca_institutions":"Montreal Heart Institute","funders":"National Center for Research Resources; National Institute of General Medical Sciences; National Institute of Diabetes and Digestive and Kidney Diseases; National Heart, Lung, and Blood Institute","keywords":"TRPV4; Gating; Vasodilation; Chemistry; Potassium channel; Biophysics; Vascular smooth muscle; Transcellular; Transient receptor potential channel; Ion channel; SK channel; Cell biology; Endothelium; Endocrinology; Receptor; Biology; Biochemistry; Smooth muscle","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002620356,0.0002501693,0.0002946255,0.0002308692,0.0002363678,0.0006431537,0.0005243799,0.000447263,0.002622707],"category_scores_gemma":[0.0005425173,0.0001548271,0.0002988723,0.0001873165,0.0005376221,0.001134339,0.0004204149,0.0005790488,0.0007155859],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003383705,"about_ca_system_score_gemma":0.0002443041,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002809782,"about_ca_topic_score_gemma":0.0004271189,"domain_scores_codex":[0.9998081,0.00002425584,0.00001662975,0.00003362339,0.00004400617,0.00007334562],"domain_scores_gemma":[0.999799,0.00004305382,0.00004509954,0.00002976767,0.00005421822,0.00002894392],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003561786,0.00002156923,0.001202245,0.00007936454,0.000007969656,0.0001276207,0.00003868192,0.0002527825,0.991708,0.0009096921,0.0001973142,0.005098532],"study_design_scores_gemma":[0.00009221295,0.0006595315,0.05248691,0.000029731,0.00005923806,0.00101955,0.0003330818,0.007485616,0.9260832,0.004922722,0.006793543,0.00003459747],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9619249,0.004257157,0.02520622,0.0008778321,0.00009322556,0.00004731182,0.0004348204,0.0004214987,0.006737117],"genre_scores_gemma":[0.9940907,0.0007364336,0.003311143,0.0001108311,0.00004120899,0.00002190717,0.0001573721,0.00001944516,0.001510822],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002622707,"threshold_uncertainty_score":0.008773804,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03471136893369143,"score_gpt":0.271526070476263,"score_spread":0.2368147015425716,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}