{"id":"W2048585008","doi":"10.1097/aln.0000000000000490","title":"5-HT1A Receptor Agonist Befiradol Reduces Fentanyl-induced Respiratory Depression, Analgesia, and Sedation in Rats","year":2014,"lang":"en","type":"article","venue":"Anesthesiology","topic":"Neuroscience of respiration and sleep","field":"Neuroscience","cited_by":52,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Health Economics","funders":"Canadian Institutes of Health Research","keywords":"Medicine; Anesthesia; Fentanyl; Agonist; Sedation; Nociception; Respiratory system; Opioid; Saline; Pharmacology; Internal medicine; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002107395,0.0005812085,0.0005926579,0.0003628124,0.0001718959,0.000199739,0.0003892558,0.0004225395,0.001994024],"category_scores_gemma":[0.000221724,0.0002411111,0.00035881,0.0001340321,0.0003275031,0.0003532461,0.0001551518,0.001120485,0.0004140039],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003751656,"about_ca_system_score_gemma":0.0004119987,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001327763,"about_ca_topic_score_gemma":0.003292826,"domain_scores_codex":[0.9998572,0.00001707795,0.00001496874,0.00002337011,0.00003969748,0.00004760782],"domain_scores_gemma":[0.9997088,0.00002515719,0.0001225406,0.00002759688,0.00003128893,0.00008452628],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002735919,0.0005974383,0.0004234603,0.0001171275,0.00002904184,0.00007003941,0.00003798094,0.00008312644,0.991493,0.00003625508,0.0001253414,0.004251216],"study_design_scores_gemma":[0.0006269133,0.02106327,0.01689295,0.00003988044,0.0001391125,0.0003476087,0.0001492833,0.001459051,0.9578689,0.00005293921,0.001331026,0.00002908985],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9967096,0.001406363,0.0006933783,0.0001636122,0.0000337494,0.00003543038,0.0002748053,0.00008821712,0.0005947644],"genre_scores_gemma":[0.9926096,0.002114003,0.001889052,0.0001515211,0.00002368611,0.00009449179,0.0004464251,0.00001728984,0.002654026],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001994024,"threshold_uncertainty_score":0.006670654,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03917647028862821,"score_gpt":0.2842779491867796,"score_spread":0.2451014788981514,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}