{"id":"W2048595956","doi":"10.1021/bi201342b","title":"Retinal Degeneration 3 (RD3) Protein Inhibits Catalytic Activity of Retinal Membrane Guanylyl Cyclase (RetGC) and Its Stimulation by Activating Proteins","year":2011,"lang":"en","type":"article","venue":"Biochemistry","topic":"Retinal Development and Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":51,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"National Eye Institute","keywords":"Visual phototransduction; Biology; Retinal; Guanylate cyclase; Intracellular; Mutant; Cell biology; Retinal degeneration; Stimulation; Biochemistry; Allosteric regulation; Receptor; Gene; Endocrinology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001514624,0.0004413257,0.0003558675,0.0001417412,0.0001786351,0.0001673131,0.0001854765,0.0003556717,0.0008636194],"category_scores_gemma":[0.0001576735,0.0001178771,0.0005556343,0.0001239315,0.0002730037,0.0001004361,0.0001803575,0.000538883,0.0002764429],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004848331,"about_ca_system_score_gemma":0.0002218668,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001421697,"about_ca_topic_score_gemma":0.001421853,"domain_scores_codex":[0.9998525,0.00002102342,0.00001913168,0.00004133826,0.00003758923,0.00002836083],"domain_scores_gemma":[0.9999011,0.00002275623,0.00002863786,0.0000143939,0.00001045012,0.0000226443],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003846394,0.00000736411,0.0001389895,0.00001652976,0.000003560192,0.00003695599,0.000005534442,0.00001513749,0.9994234,0.00003313538,0.00001596348,0.0002649424],"study_design_scores_gemma":[0.00001736922,0.0001992579,0.009069988,0.00000638669,0.00002254943,0.0006376174,0.00001364725,0.000607134,0.9874883,0.00004947525,0.00188354,0.000004657027],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.991944,0.003334503,0.002929479,0.000160884,0.00004802402,0.00002024736,0.000425964,0.0001412826,0.0009956899],"genre_scores_gemma":[0.9943166,0.0009492685,0.002408519,0.0001137482,0.000008264689,0.00002749214,0.0006121396,0.00003056543,0.001533287],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001421697,"threshold_uncertainty_score":0.003517747,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01437314454789183,"score_gpt":0.2243680127093418,"score_spread":0.20999486816145,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}