{"id":"W2048600890","doi":"10.1158/0008-5472.can-05-4572","title":"Novel 5′ Untranslated Region Variants of <i>BCRP</i> mRNA Are Differentially Expressed in Drug-Selected Cancer Cells and in Normal Human Tissues: Implications for Drug Resistance, Tissue-Specific Expression, and Alternative Promoter Usage","year":2006,"lang":"en","type":"article","venue":"Cancer Research","topic":"Drug Transport and Resistance Mechanisms","field":"Medicine","cited_by":70,"is_retracted":false,"has_abstract":true,"ca_institutions":"Immunovaccine (Canada)","funders":"","keywords":"Exon; Gene isoform; Biology; Abcg2; Untranslated region; Alternative splicing; Molecular biology; Promoter; Gene; Gene expression; Cell culture; Serial analysis of gene expression; Cancer cell; Cancer research; Cancer; Messenger RNA; Genetics; Transcriptome; ATP-binding cassette transporter; Transporter","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001145627,0.0002125689,0.0001705762,0.000325087,0.0001088136,0.0002586372,0.0001067647,0.0002165457,0.0009567323],"category_scores_gemma":[0.0001902712,0.0001582623,0.000202608,0.0001876702,0.0001767077,0.0001054614,0.00009440849,0.0002622678,0.0003992024],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001481885,"about_ca_system_score_gemma":0.0001048525,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002629992,"about_ca_topic_score_gemma":0.0004213136,"domain_scores_codex":[0.9998521,0.00001416378,0.00001332573,0.00005848286,0.00003065044,0.00003129266],"domain_scores_gemma":[0.9997652,0.00006855961,0.00008204313,0.00002678501,0.0000303002,0.00002714189],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.00005751988,0.000004977159,0.0008277094,0.00001347507,0.000002876117,0.0001252824,0.00001994117,0.00001613104,0.9981613,0.00003049766,0.00001469451,0.000725739],"study_design_scores_gemma":[0.00001851289,0.0002973061,0.1049135,0.00001298194,0.00004019583,0.005231931,0.00009837133,0.0005399094,0.8852819,0.0001063125,0.003446875,0.00001216221],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9967508,0.0005988528,0.001562822,0.00003386057,0.000006860076,0.00001155761,0.0005154931,0.00003532236,0.0004844007],"genre_scores_gemma":[0.9926323,0.0004609255,0.003496085,0.00006472043,0.00001684269,0.00003203154,0.002169589,0.00002601808,0.001101409],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009567323,"threshold_uncertainty_score":0.00320065,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04222226744865033,"score_gpt":0.3388837418925684,"score_spread":0.2966614744439181,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}