{"id":"W2048600890","doi":"10.1158/0008-5472.can-05-4572","title":"Novel 5′ Untranslated Region Variants of <i>BCRP</i> mRNA Are Differentially Expressed in Drug-Selected Cancer Cells and in Normal Human Tissues: Implications for Drug Resistance, Tissue-Specific Expression, and Alternative Promoter Usage","year":2006,"lang":"en","type":"article","venue":"Cancer Research","topic":"Drug Transport and Resistance Mechanisms","field":"Medicine","cited_by":70,"is_retracted":false,"has_abstract":true,"ca_institutions":"Immunovaccine (Canada)","funders":"","keywords":"Exon; Gene isoform; Biology; Abcg2; Untranslated region; Alternative splicing; Molecular biology; Promoter; Gene; Gene expression; Cell culture; Serial analysis of gene expression; Cancer cell; Cancer research; Cancer; Messenger RNA; Genetics; Transcriptome; ATP-binding cassette transporter; Transporter","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003924812,0.0002423184,0.0005299067,0.0004648057,0.0001751394,0.00003993992,0.000204682,0.0001377695,0.00004341546],"category_scores_gemma":[0.00001213623,0.0002140219,0.00003715507,0.0007752621,0.000267952,0.0001485699,0.00003736766,0.0004232078,3.312288e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001572193,"about_ca_system_score_gemma":0.0001779238,"about_ca_topic_candidate":true,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002142253,"about_ca_topic_score_gemma":0.02076435,"domain_scores_codex":[0.9976243,0.0001075365,0.0005721591,0.0006747791,0.000410704,0.000610486],"domain_scores_gemma":[0.998742,0.0001273907,0.0001603874,0.0003355598,0.000493203,0.0001414655],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001219047,0.0003597921,0.006720408,0.0006858981,0.00002269837,0.00002974595,0.00153643,0.00001476426,0.9870845,0.0002202171,0.001733649,0.0003728654],"study_design_scores_gemma":[0.00633816,0.00005434989,0.1587077,0.002506826,0.00002950704,0.00000211911,0.0001644417,0.00002276623,0.8268868,0.001127791,0.003901432,0.00025809],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9915899,0.003373333,0.0009599927,0.001222693,0.00007481326,0.002169991,0.0003578175,0.00002607906,0.0002253498],"genre_scores_gemma":[0.9920775,0.002094056,0.000752427,0.00001655277,0.0001346238,0.0008353018,0.00007823781,0.0000558125,0.003955447],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1601977,"threshold_uncertainty_score":0.9971042,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04222226744865033,"score_gpt":0.3388837418925684,"score_spread":0.2966614744439181,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}