{"id":"W2048626535","doi":"10.1002/stem.576","title":"An Endothelial Cell Niche Induces Hepatic Specification Through Dual Repression of Wnt and Notch Signaling","year":2010,"lang":"en","type":"article","venue":"Stem Cells","topic":"Congenital heart defects research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":66,"is_retracted":false,"has_abstract":true,"ca_institutions":"University Health Network","funders":"National Institute of Diabetes and Digestive and Kidney Diseases","keywords":"Endoderm; Biology; Cell biology; Notch signaling pathway; Wnt signaling pathway; Fibroblast growth factor; Mesoderm; Embryonic stem cell; Signal transduction; Genetics; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000214591,0.00009392358,0.0001087168,0.00002457708,0.00005268751,0.00002298592,0.0001077913,0.0001153001,0.00003674276],"category_scores_gemma":[0.00001130758,0.00008382164,0.00003575575,0.00005205121,0.00007398381,0.000007832869,0.00008036507,0.0001403069,0.00001053708],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000003649772,"about_ca_system_score_gemma":0.00004707062,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000393974,"about_ca_topic_score_gemma":0.00002687116,"domain_scores_codex":[0.9991238,0.00008190526,0.0001770907,0.0003030965,0.0001579578,0.0001561322],"domain_scores_gemma":[0.9994038,0.00003524749,0.00006687979,0.0003553681,0.00007384008,0.00006490944],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004810154,0.00006182101,0.0005762938,0.00004998032,0.000006122094,0.00000210697,0.0001906307,0.000004762258,0.9952301,0.00001066025,0.0000274386,0.003791923],"study_design_scores_gemma":[0.0002553384,0.0002638854,0.0003344138,0.0000089806,0.00000761695,0.000005601404,0.0001266257,0.00006497366,0.9976361,0.0000338125,0.001169865,0.00009280734],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9982725,0.0002396091,0.00006835733,0.0000147993,0.0001382373,0.0002145157,0.00001876077,0.000006550059,0.001026648],"genre_scores_gemma":[0.9987297,0.00008538079,0.0004889013,0.00001187797,0.0001816112,0.000008129264,0.00001722689,0.00001618127,0.0004609769],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003699115,"threshold_uncertainty_score":0.3418147,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01879884856890594,"score_gpt":0.2877534468707304,"score_spread":0.2689545983018244,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}