{"id":"W2048626535","doi":"10.1002/stem.576","title":"An Endothelial Cell Niche Induces Hepatic Specification Through Dual Repression of Wnt and Notch Signaling","year":2010,"lang":"en","type":"article","venue":"Stem Cells","topic":"Congenital heart defects research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":66,"is_retracted":false,"has_abstract":true,"ca_institutions":"University Health Network","funders":"National Institute of Diabetes and Digestive and Kidney Diseases","keywords":"Endoderm; Biology; Cell biology; Notch signaling pathway; Wnt signaling pathway; Fibroblast growth factor; Mesoderm; Embryonic stem cell; Signal transduction; Genetics; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001310564,0.0002281373,0.0001518492,0.0002753476,0.0001244236,0.0003456634,0.000181366,0.000130055,0.0009913712],"category_scores_gemma":[0.0000839311,0.0001855535,0.0001683944,0.0001389457,0.000189248,0.0001165853,0.0002801623,0.0003970721,0.0002846029],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003938438,"about_ca_system_score_gemma":0.0002838853,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006702963,"about_ca_topic_score_gemma":0.0016615,"domain_scores_codex":[0.9998268,0.0000230264,0.00002033356,0.00002986812,0.00006126722,0.00003858934],"domain_scores_gemma":[0.9998821,0.00001673662,0.00003425036,0.00001227124,0.00001143986,0.00004326894],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003809676,0.00001049412,0.0001634896,0.00001483455,0.000002118667,0.00004599473,0.00000963249,0.00002799182,0.9988978,0.0002318368,0.00001944266,0.0005382313],"study_design_scores_gemma":[0.00001108192,0.00007235499,0.003185102,0.000004101034,0.000008694319,0.0001346061,0.00001726516,0.000686283,0.9939861,0.00004136395,0.001850963,0.000002021103],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9922822,0.0007755383,0.003611996,0.00006277121,0.00002019264,0.00002106092,0.0002980822,0.000095686,0.002832396],"genre_scores_gemma":[0.990513,0.0006044675,0.003006593,0.00005115468,0.00001140913,0.00002785941,0.0003958372,0.00002559951,0.005364007],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009913712,"threshold_uncertainty_score":0.003316462,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01879884856890594,"score_gpt":0.2877534468707304,"score_spread":0.2689545983018244,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}