{"id":"W2048669313","doi":"10.1021/jm401530a","title":"Structure–Activity Relationships of Synthetic Cordycepin Analogues as Experimental Therapeutics for African Trypanosomiasis","year":2013,"lang":"en","type":"article","venue":"Journal of Medicinal Chemistry","topic":"Trypanosoma species research and implications","field":"Medicine","cited_by":66,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"","keywords":"Cordycepin; Trypanosoma brucei; Chemistry; Adenosine deaminase; Deoxyadenosine; African trypanosomiasis; Adenosine kinase; In vivo; Trypanocidal agent; Adenosine; In vitro; Biochemistry; Pharmacology; Trypanosomiasis; Biology; Virology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001259811,0.0002675708,0.0002706074,0.0001812561,0.0000824359,0.0001630155,0.0001722623,0.000176759,0.001759238],"category_scores_gemma":[0.0001989599,0.00008082038,0.0001372885,0.0001649267,0.0001333644,0.0001498523,0.0001040361,0.0003086745,0.0002053663],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002774029,"about_ca_system_score_gemma":0.0001874645,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006220651,"about_ca_topic_score_gemma":0.001127434,"domain_scores_codex":[0.9999491,0.00001321804,0.000006741237,0.000008947013,0.00001114134,0.0000108346],"domain_scores_gemma":[0.9999144,0.00001847513,0.00002276619,0.000006717778,0.00001289677,0.00002472166],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001058411,0.0002854628,0.0003303733,0.000244533,0.0000216737,0.0001396025,0.00002950882,0.001593221,0.9813068,0.0003000325,0.0001800532,0.01451031],"study_design_scores_gemma":[0.0007187671,0.01272651,0.005763093,0.00004551065,0.00009849622,0.0005739919,0.00003088324,0.002486645,0.964723,0.0001630234,0.01264964,0.00002047077],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9798403,0.01324098,0.001451126,0.000142378,0.0000426656,0.000174773,0.0008729532,0.0000416193,0.004193241],"genre_scores_gemma":[0.9908597,0.004841099,0.002105643,0.00006656307,0.00001842225,0.00004622705,0.0007957684,0.000007622943,0.00125908],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001759238,"threshold_uncertainty_score":0.005885243,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05210131156741535,"score_gpt":0.337828265286442,"score_spread":0.2857269537190267,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}