{"id":"W2048673311","doi":"10.1016/j.ijpharm.2013.11.045","title":"Aspects of nonviral gene therapy: Correlation of molecular parameters with lipoplex structure and transfection efficacy in pyridinium-based cationic lipids","year":2013,"lang":"en","type":"article","venue":"International Journal of Pharmaceutics","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":22,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Victoria","funders":"","keywords":"Transfection; Lipofectamine; Cationic polymerization; Phosphatidylethanolamine; Chinese hamster ovary cell; Chemistry; Pyridinium; Biophysics; Liposome; Gene delivery; Biochemistry; Phosphatidylcholine; Phospholipid; Biology; Membrane; Organic chemistry; Recombinant DNA; Gene; Vector (molecular biology)","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0000918588,0.00009226512,0.0001278498,0.0001383374,0.000008833597,0.00001357783,0.0001428942,0.00006841601,0.00002177327],"category_scores_gemma":[0.00002150458,0.00007764008,0.00006132274,0.00006714975,0.00006570508,0.00001866354,0.00001088524,0.0001142937,3.132991e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002016683,"about_ca_system_score_gemma":0.00009596653,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000302768,"about_ca_topic_score_gemma":0.00001101821,"domain_scores_codex":[0.9992492,0.00004779654,0.0003193205,0.00009794434,0.0002114066,0.00007432515],"domain_scores_gemma":[0.9991913,0.00002157762,0.0002656092,0.00006948424,0.0004151083,0.00003695091],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004381315,0.0001181046,0.009872603,0.000008593777,0.0001597361,0.000003582772,0.00009068043,0.02200376,0.9600253,0.00001819141,0.00000766097,0.007253724],"study_design_scores_gemma":[0.002117974,0.0005828451,0.01733648,0.00004275863,0.00002700178,0.00004103449,0.00002545881,0.002626458,0.976979,0.00008062887,0.00006583716,0.00007457481],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9950194,0.0004515725,0.003982213,0.0001723652,0.0002111072,0.0001206345,0.00001192965,0.000001150882,0.00002958769],"genre_scores_gemma":[0.9986133,0.0004265404,0.0007349767,0.0001204454,0.00006600083,0.000001778064,0.00002394158,0.00000933859,0.000003673188],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01937731,"threshold_uncertainty_score":0.3166071,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01359554666565712,"score_gpt":0.282530227119766,"score_spread":0.2689346804541089,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}