{"id":"W2048673311","doi":"10.1016/j.ijpharm.2013.11.045","title":"Aspects of nonviral gene therapy: Correlation of molecular parameters with lipoplex structure and transfection efficacy in pyridinium-based cationic lipids","year":2013,"lang":"en","type":"article","venue":"International Journal of Pharmaceutics","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":22,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Victoria","funders":"","keywords":"Transfection; Lipofectamine; Cationic polymerization; Phosphatidylethanolamine; Chinese hamster ovary cell; Chemistry; Pyridinium; Biophysics; Liposome; Gene delivery; Biochemistry; Phosphatidylcholine; Phospholipid; Biology; Membrane; Organic chemistry; Recombinant DNA; Gene; Vector (molecular biology)","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008977776,0.0004026825,0.0002899125,0.0002791918,0.0001564556,0.0006634722,0.0003259476,0.0004932351,0.0005663052],"category_scores_gemma":[0.001596731,0.0002791338,0.0001994977,0.0002446414,0.0005138073,0.0008800845,0.0002718447,0.0005774144,0.0002756345],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003733008,"about_ca_system_score_gemma":0.0003329882,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002765663,"about_ca_topic_score_gemma":0.0001960353,"domain_scores_codex":[0.9996112,0.0001518342,0.00003271005,0.00004984985,0.0001133756,0.00004115279],"domain_scores_gemma":[0.9988543,0.0006608006,0.0002643316,0.00005911855,0.00009921722,0.00006224121],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000202899,0.00002646641,0.0003645644,0.00003922886,0.00000388331,0.00003054704,0.00003163967,0.0003404946,0.9971502,0.0001377398,0.00001276659,0.001659575],"study_design_scores_gemma":[0.000005153802,0.0001575589,0.001050154,0.000002068606,0.000007991262,0.00008174105,0.00001212243,0.001088968,0.9973311,0.00008628489,0.0001713029,0.000005596203],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9827743,0.002489898,0.0137389,0.0001269537,0.00001181071,0.00005394718,0.00008926865,0.00005779238,0.0006572633],"genre_scores_gemma":[0.9960891,0.0009827482,0.002290154,0.00003112879,0.00001013575,0.00003034929,0.00008173016,0.00002116557,0.0004635494],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008977776,"threshold_uncertainty_score":0.004747987,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01359554666565712,"score_gpt":0.282530227119766,"score_spread":0.2689346804541089,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}