{"id":"W2048675682","doi":"10.1021/jm2014056","title":"Niphatenones, Glycerol Ethers from the Sponge <i>Niphates digitalis</i> Block Androgen Receptor Transcriptional Activity in Prostate Cancer Cells: Structure Elucidation, Synthesis, and Biological Activity","year":2011,"lang":"en","type":"article","venue":"Journal of Medicinal Chemistry","topic":"Marine Sponges and Natural Products","field":"Biochemistry, Genetics and Molecular Biology","cited_by":69,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Cancer Agency; University of British Columbia","funders":"","keywords":"LNCaP; Chemistry; Androgen receptor; Biological activity; Pharmacophore; Prostate cancer; Stereochemistry; Biochemistry; Pharmacology; Cancer; In vitro; Internal medicine; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003436463,0.0002008966,0.0002612622,0.00001781919,0.00005873564,0.0000189283,0.0002280081,0.0001818268,0.0002013545],"category_scores_gemma":[0.0001515023,0.0001219032,0.0000785465,0.0000817963,0.0001881705,0.00002475004,0.00005392848,0.0003904598,2.73136e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000298952,"about_ca_system_score_gemma":0.0001138096,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002098521,"about_ca_topic_score_gemma":0.00006105131,"domain_scores_codex":[0.9989492,0.00009200903,0.0002558829,0.0002783794,0.0002253153,0.0001992361],"domain_scores_gemma":[0.9992627,0.00005962723,0.0002794143,0.0001605882,0.0001222859,0.0001154183],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001814372,0.00007722375,0.0163864,0.00003346673,0.0001075639,0.00001417681,0.0001449547,0.00000524944,0.9726363,5.147668e-7,0.0005725895,0.008207127],"study_design_scores_gemma":[0.0006967848,0.0001263914,0.03877299,0.00006749408,0.00005074165,0.00009323415,0.0001170981,0.000005806619,0.9554161,0.00004890584,0.004453474,0.0001510223],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9938676,0.004637903,0.000003665344,0.0009533345,0.0001576581,0.0001125647,0.0001923344,0.000003461058,0.00007145325],"genre_scores_gemma":[0.996394,0.002734925,0.00006797655,0.000107792,0.000597392,0.000005433561,0.0000265342,0.00001273866,0.00005318324],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02238659,"threshold_uncertainty_score":0.4971067,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01585649323401887,"score_gpt":0.2293135459126439,"score_spread":0.213457052678625,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}