{"id":"W2048675682","doi":"10.1021/jm2014056","title":"Niphatenones, Glycerol Ethers from the Sponge <i>Niphates digitalis</i> Block Androgen Receptor Transcriptional Activity in Prostate Cancer Cells: Structure Elucidation, Synthesis, and Biological Activity","year":2011,"lang":"en","type":"article","venue":"Journal of Medicinal Chemistry","topic":"Marine Sponges and Natural Products","field":"Biochemistry, Genetics and Molecular Biology","cited_by":69,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Cancer Agency; University of British Columbia","funders":"","keywords":"LNCaP; Chemistry; Androgen receptor; Biological activity; Pharmacophore; Prostate cancer; Stereochemistry; Biochemistry; Pharmacology; Cancer; In vitro; Internal medicine; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00004737282,0.0002940822,0.0001074129,0.000163256,0.00009015135,0.0001272692,0.0001058082,0.00009652397,0.001914998],"category_scores_gemma":[0.00005661497,0.00007148674,0.0001356309,0.0001111097,0.0001580909,0.0001581694,0.0001443289,0.000278551,0.0003227253],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001571332,"about_ca_system_score_gemma":0.000196535,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006078514,"about_ca_topic_score_gemma":0.001876862,"domain_scores_codex":[0.9999712,0.000003411016,0.00000253394,0.000005387279,0.000008728704,0.000008790723],"domain_scores_gemma":[0.9999751,0.000003819294,0.000006357315,0.000002700712,0.000003416857,0.000008561836],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001303555,0.00001572949,0.0001915506,0.00007199935,0.000004562592,0.0000747442,0.000008115182,0.0001082667,0.9951569,0.0001001899,0.00004384149,0.004093641],"study_design_scores_gemma":[0.00002223519,0.0004491428,0.004268165,0.000007758664,0.00001792026,0.0002311714,0.00002611248,0.000214422,0.9885876,0.00005325309,0.00611559,0.000006628317],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.981346,0.00409366,0.003834349,0.000194257,0.00004081147,0.0001115501,0.001317396,0.00008490573,0.00897709],"genre_scores_gemma":[0.988393,0.003371913,0.002086662,0.0001079824,0.00001232366,0.00003788335,0.0009970473,0.00001195895,0.004981214],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001914998,"threshold_uncertainty_score":0.006406367,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01585649323401887,"score_gpt":0.2293135459126439,"score_spread":0.213457052678625,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}