{"id":"W2048690216","doi":"10.1371/journal.pone.0016756","title":"The Obesity-Associated Polymorphisms FTO rs9939609 and MC4R rs17782313 and Endometrial Cancer Risk in Non-Hispanic White Women","year":2011,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Cancer-related molecular mechanisms research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":66,"is_retracted":false,"has_abstract":true,"ca_institutions":"Women's College Hospital; University of Toronto","funders":"Division of Cancer Epidemiology and Genetics, National Cancer Institute; National Cancer Institute; Care and Public Health Research Institute, Universiteit Maastricht; National Health and Medical Research Council; Canadian Institutes of Health Research; U.S. Public Health Service; School of Medicine, Vanderbilt University; School of Medicine, New York University; National Institutes of Health; Universitätsklinikum Erlangen; Eunice Kennedy Shriver National Institute of Child Health and Human Development; Karolinska Institutet; Universiteit Maastricht; Vlaamse regering; Vanderbilt-Ingram Cancer Center; University of Oxford; Brigham and Women's Hospital; Queensland University of Technology; Rutgers Cancer Institute of New Jersey; Barbara Ann Karmanos Cancer Institute; Vanderbilt University Medical Center; Yale Cancer Center; University of Southern California; Beckman Research Institute, City of Hope; University of Pittsburgh; Memorial Sloan-Kettering Cancer Center; University of Washington; Johns Hopkins University; Centre Hospitalier Universitaire Vaudois; Imperial College London; York University; Alberta Health Services; Cancer Institute, University of Pittsburgh; University of Minnesota; University of Pennsylvania; University of Toronto; Yale University; Johns Hopkins Bloomberg School of Public Health; Vanderbilt University; Universitetet i Oslo; Wayne State University; U.S. Department of Health and Human Services","keywords":"Endometrial cancer; Medicine; Obesity; Overweight; Internal medicine; Odds ratio; Body mass index; Oncology; FTO gene; Gynecology; Genotype; Endocrinology; Cancer; Polymorphism (computer science); Genetics; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009070595,0.0003408055,0.0004604145,0.0007463397,0.0002548567,0.0003872963,0.0002393671,0.0004191705,0.001114478],"category_scores_gemma":[0.001955048,0.0003092245,0.0006964954,0.000890334,0.0002007353,0.0001483086,0.0002989823,0.0002971196,0.0001162255],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001560992,"about_ca_system_score_gemma":0.0001828895,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.005146662,"about_ca_topic_score_gemma":0.005744569,"domain_scores_codex":[0.9996436,0.00009636442,0.000045118,0.0001020949,0.00007090953,0.00004187543],"domain_scores_gemma":[0.9992517,0.000183159,0.0003400254,0.00009638922,0.00005059166,0.00007814306],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001250508,0.00003098514,0.9908224,0.0000287928,0.001025374,0.000290298,0.00006108197,0.00008746244,0.002825127,0.00002674045,0.00008919633,0.003461954],"study_design_scores_gemma":[0.00004172558,0.00008389638,0.9985459,0.000006541116,0.0003371849,0.0002960868,0.00003836542,0.0002359822,0.0001719143,0.00006704373,0.0001720196,0.000003500266],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9984761,0.0009750263,0.0001199568,0.00003189458,0.000005943542,0.000004881668,0.0001773119,0.000003717094,0.0002052334],"genre_scores_gemma":[0.999173,0.0002620126,0.0001103144,0.00002819527,0.00001495644,0.000006663289,0.0002323439,0.000002910867,0.0001695282],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005146662,"threshold_uncertainty_score":0.0102334,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02006050573250695,"score_gpt":0.2293484198454734,"score_spread":0.2092879141129665,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}