{"id":"W2048732558","doi":"10.1007/s40264-015-0275-y","title":"Comparative Safety and Tolerability of Endothelin Receptor Antagonists in Pulmonary Arterial Hypertension","year":2015,"lang":"en","type":"review","venue":"Drug Safety","topic":"Pulmonary Hypertension Research and Treatments","field":"Medicine","cited_by":32,"is_retracted":false,"has_abstract":false,"ca_institutions":"Toronto General Hospital","funders":"Actelion Pharmaceuticals; University Health Network Foundation; University Health Network; GlaxoSmithKline","keywords":"Ambrisentan; Medicine; Bosentan; Tolerability; Peripheral edema; Adverse effect; Endothelin receptor antagonist; Pharmacology; Intensive care medicine; Population; Endothelin receptor; Internal medicine; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001701125,0.0005647471,0.002995586,0.001364287,0.0001229268,0.0007878349,0.0008733573,0.0007320773,0.003038478],"category_scores_gemma":[0.002456439,0.0002382635,0.001827608,0.001335691,0.0002754637,0.0007920216,0.0003691577,0.00110771,0.0003244195],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003243802,"about_ca_system_score_gemma":0.0006809105,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006328892,"about_ca_topic_score_gemma":0.001690829,"domain_scores_codex":[0.9994457,0.0001296203,0.0001795463,0.00006160824,0.0001598649,0.00002360965],"domain_scores_gemma":[0.9981337,0.001282973,0.000347058,0.00002355347,0.0001785762,0.00003406929],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.001983455,0.0001773053,0.0006400794,0.122716,0.003432998,0.0001962907,0.00008702502,0.0004272976,0.00285101,0.0008118965,0.005038762,0.8616378],"study_design_scores_gemma":[0.006148694,0.009620843,0.03201532,0.106347,0.06058285,0.006289674,0.0007724758,0.00146469,0.009053462,0.005593067,0.7617799,0.0003321265],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0007659071,0.9987656,0.00007244695,0.00007192842,0.00004048333,0.000008077237,0.00003407812,0.00000216317,0.0002393173],"genre_scores_gemma":[0.005585954,0.993719,0.0002116689,0.000191086,0.00008087727,0.000009381957,0.00005222535,0.000001327722,0.0001485351],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.003038478,"threshold_uncertainty_score":0.01016468,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07548638903000758,"score_gpt":0.3591478479243453,"score_spread":0.2836614588943377,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}