{"id":"W2048748552","doi":"10.1021/es800591t","title":"Responses of the Medaka HPG Axis PCR Array and Reproduction to Prochloraz and Ketoconazole","year":2008,"lang":"en","type":"article","venue":"Environmental Science & Technology","topic":"Reproductive biology and impacts on aquatic species","field":"Biochemistry, Genetics and Molecular Biology","cited_by":91,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Saskatchewan","funders":"U.S. Environmental Protection Agency","keywords":"Fecundity; Vitellogenin; Biology; Ketoconazole; Aromatase; Estrogen receptor; Oryzias; Andrology; Cytochrome P450; Endocrinology; Internal medicine; Downregulation and upregulation; Metabolism; Gene; Genetics; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00005585498,0.0002907077,0.0001738827,0.0001845923,0.0001273131,0.0001875853,0.0001250573,0.0001997861,0.001693276],"category_scores_gemma":[0.00008750642,0.000170116,0.0002035152,0.0001413689,0.0002141751,0.0001079915,0.0001127385,0.0002937958,0.0002469683],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003159823,"about_ca_system_score_gemma":0.0001780214,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002172069,"about_ca_topic_score_gemma":0.004961193,"domain_scores_codex":[0.999893,0.000009724859,0.000007435303,0.00004556735,0.00002494804,0.00001945791],"domain_scores_gemma":[0.9999141,0.00001210509,0.00002949353,0.000006140157,0.00002369802,0.00001452248],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001342711,0.000009307669,0.0007689944,0.00002361721,0.000003772474,0.00001183642,0.00001784631,0.00003575665,0.9980364,0.0000114329,0.00003258367,0.0009141424],"study_design_scores_gemma":[0.00001535209,0.0006657876,0.06174072,0.000004216682,0.00003665675,0.00007567575,0.000120076,0.000644467,0.9352699,0.00002677273,0.001390612,0.00000968439],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9946705,0.0007970893,0.001616636,0.00009466893,0.00003104209,0.000026929,0.001255213,0.0001022759,0.001405708],"genre_scores_gemma":[0.9854418,0.0008236857,0.003679555,0.0001962272,0.00001779948,0.000137317,0.002016911,0.00002455898,0.007662092],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002172069,"threshold_uncertainty_score":0.005664587,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00939797495641635,"score_gpt":0.2288600263052236,"score_spread":0.2194620513488073,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}