{"id":"W2048750982","doi":"10.1016/j.brainresbull.2012.05.003","title":"Molecular basis of axonal dysfunction and traffic impairments in CMT","year":2012,"lang":"en","type":"review","venue":"Brain Research Bulletin","topic":"Hereditary Neurological Disorders","field":"Neuroscience","cited_by":54,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University; Montreal Neurological Institute and Hospital","funders":"Canadian Institutes of Health Research","keywords":"Phenotype; Gene; Biology; MFN2; Neuroscience; Disease; Genetics; Loss function; Axoplasmic transport; Pathogenesis; Cell biology; Medicine; Pathology; Immunology; Mitochondrial DNA; mitochondrial fusion","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.002629007,0.0003339806,0.000897533,0.0006971879,0.00008734257,0.00003795838,0.0005702687,0.0003708943,0.001173116],"category_scores_gemma":[0.004305796,0.0002765676,0.00021682,0.001015287,0.0005539377,0.00004872607,0.0004110234,0.001350786,0.0003930225],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008430192,"about_ca_system_score_gemma":0.0001580383,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004203138,"about_ca_topic_score_gemma":0.000005607567,"domain_scores_codex":[0.9923915,0.004071381,0.000620231,0.0008535505,0.001133265,0.0009301084],"domain_scores_gemma":[0.9960428,0.003087531,0.0001393294,0.0004216988,0.00004751538,0.0002611382],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00005171884,0.0004731271,0.00001146669,0.005852206,0.0000127746,0.0004938946,0.00004323065,0.000009701269,0.000266407,0.0001569364,0.006548293,0.9860802],"study_design_scores_gemma":[0.0003506149,0.0003405618,0.00008352079,0.0008928126,0.00002062278,0.00007658402,0.00001482769,0.00001833868,0.00003345468,0.00005173489,0.9978979,0.000218998],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0102802,0.9840536,0.000004026562,0.002008557,0.0001313392,0.001862622,0.00006790724,0.00004407756,0.001547711],"genre_scores_gemma":[0.008402375,0.9905479,0.00002964897,0.0003294967,0.00006446412,0.0002751559,0.00001618593,0.00006222281,0.0002725375],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9913496,"threshold_uncertainty_score":0.9999686,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1863696238994397,"score_gpt":0.4024675906386512,"score_spread":0.2160979667392114,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}