{"id":"W2048762907","doi":"10.1002/cmdc.200900288","title":"3,5‐Bis(benzylidene)‐4‐oxo‐1‐phosphonopiperidines and Related Diethyl Esters: Potent Cytotoxins with Multi‐Drug‐Resistance Reverting Properties","year":2009,"lang":"en","type":"article","venue":"ChemMedChem","topic":"Synthesis and biological activity","field":"Chemistry","cited_by":51,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Saskatchewan","funders":"Canadian Institutes of Health Research","keywords":"Cytotoxicity; Stereochemistry; Chemistry; Reversion; Cell culture; Apoptosis; In vitro; Biochemistry; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001533232,0.0003978607,0.0004668843,0.00002486927,0.0002029885,0.0001079381,0.0002492119,0.0002185651,0.0001411942],"category_scores_gemma":[0.0003294863,0.0002568658,0.0001053619,0.0001468488,0.0002092385,0.0002283493,0.00008721738,0.0003122715,0.00001270794],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009829847,"about_ca_system_score_gemma":0.00003610793,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000370768,"about_ca_topic_score_gemma":0.00002614182,"domain_scores_codex":[0.998188,0.00002344562,0.0003862721,0.0006725332,0.0002295676,0.0005002172],"domain_scores_gemma":[0.9990048,0.0001017976,0.0002111524,0.0003962343,0.00009817324,0.0001878397],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001377262,0.0002491196,0.001893802,0.000145825,0.00005186995,0.00002754214,0.0004245815,0.000002213818,0.9891728,0.00001092763,0.0001860381,0.007697567],"study_design_scores_gemma":[0.0006455471,0.00003496517,0.006143786,0.0004571448,0.00003423767,0.00002007163,0.0005697741,0.0001158418,0.9906178,0.00008238186,0.0008078421,0.0004706166],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9904395,0.00234259,0.00001454077,0.00219417,0.00003084298,0.0001708552,0.000005830237,0.0002397062,0.004561906],"genre_scores_gemma":[0.9925174,0.0001635053,0.001462521,0.0002524032,0.00007958931,0.00005082435,0.000008929464,0.00002869761,0.005436142],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00722695,"threshold_uncertainty_score":0.9999884,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01995849693572397,"score_gpt":0.2029555268616185,"score_spread":0.1829970299258945,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}