{"id":"W2048762907","doi":"10.1002/cmdc.200900288","title":"3,5‐Bis(benzylidene)‐4‐oxo‐1‐phosphonopiperidines and Related Diethyl Esters: Potent Cytotoxins with Multi‐Drug‐Resistance Reverting Properties","year":2009,"lang":"en","type":"article","venue":"ChemMedChem","topic":"Synthesis and biological activity","field":"Chemistry","cited_by":51,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Saskatchewan","funders":"Canadian Institutes of Health Research","keywords":"Cytotoxicity; Stereochemistry; Chemistry; Reversion; Cell culture; Apoptosis; In vitro; Biochemistry; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001258364,0.0002727209,0.0001688365,0.0001341399,0.00007355521,0.0001715994,0.0002346351,0.0001712971,0.001295384],"category_scores_gemma":[0.0001439298,0.0001093145,0.0001539738,0.0001167569,0.0001229901,0.0003057982,0.0001862094,0.0005148894,0.0004377672],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001552365,"about_ca_system_score_gemma":0.0001537083,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000172711,"about_ca_topic_score_gemma":0.0003858625,"domain_scores_codex":[0.999943,0.00001378596,0.000006582745,0.000009460133,0.00001133995,0.00001584066],"domain_scores_gemma":[0.9999301,0.00001254414,0.00002413262,0.000009506516,0.000008236482,0.0000154502],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003010148,0.0001175614,0.0003392453,0.0001589007,0.000009992593,0.0001699156,0.00004695117,0.0009080261,0.9825434,0.0007199897,0.0001501293,0.01453492],"study_design_scores_gemma":[0.00007826886,0.002197154,0.002392193,0.00001362642,0.00002318635,0.0005854293,0.00002258074,0.0009550598,0.9842906,0.0001147351,0.009316658,0.00001048252],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9816233,0.003710515,0.006889717,0.00015429,0.00004224421,0.0001176542,0.0004397616,0.0001075931,0.006914988],"genre_scores_gemma":[0.9871815,0.003081669,0.005892203,0.00007220458,0.00001448247,0.00005949545,0.0005334222,0.00001673598,0.003148341],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001295384,"threshold_uncertainty_score":0.004333496,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01995849693572397,"score_gpt":0.2029555268616185,"score_spread":0.1829970299258945,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}